{"id":"W4398193890","doi":"10.1016/j.jcyt.2024.03.123","title":"IL6 SIGNALING IN MESENCHYMAL STROMAL CELLS INTERACTIONS WITH MONOCYTE/MACROPHAGE INDUCES PRO-RESOLVING PHENOTYPES AND FUNCTIONALITY IN OSTEOARTHRITIS","year":2024,"lang":"en","type":"article","venue":"Cytotherapy","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Mesenchymal stem cell; Phenotype; Macrophage; Monocyte; Stromal cell; Cell biology; Osteoarthritis; Chemistry; Cancer research; Biology; Immunology; Medicine; Pathology; In vitro; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000254417,0.0003297645,0.0002397996,0.0003157908,0.0002758072,0.0004804312,0.0001168515,0.0003847521,0.002596965],"category_scores_gemma":[0.0001024802,0.0001281005,0.000321957,0.0001851064,0.000248169,0.0001891158,0.0002008791,0.0009838322,0.0006223073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001834061,"about_ca_system_score_gemma":0.0002601827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003344335,"about_ca_topic_score_gemma":0.0007641048,"domain_scores_codex":[0.9997166,0.00007498034,0.0000243563,0.00002458866,0.00007267004,0.00008687442],"domain_scores_gemma":[0.9999217,0.00001001536,0.00001930017,0.000006202933,0.00001112513,0.0000317478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000574814,0.00009009333,0.0003184891,0.00008823566,0.000007755727,0.00008070178,0.00003017314,0.00006049358,0.9961123,0.0002053245,0.0000917238,0.002339933],"study_design_scores_gemma":[0.00006996725,0.0008507039,0.005141326,0.00001831237,0.00003426563,0.0002149572,0.000146072,0.0004410648,0.9885351,0.0001066062,0.004435658,0.000005904103],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887934,0.005340464,0.002091524,0.000382666,0.0001269323,0.0000385675,0.0003667852,0.00006481115,0.002794744],"genre_scores_gemma":[0.993717,0.001589066,0.0009723377,0.0001264602,0.00002941107,0.00004334657,0.0002557586,0.000007293384,0.003259448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002596965,"threshold_uncertainty_score":0.008687735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02326294672653813,"score_gpt":0.288106143875325,"score_spread":0.2648431971487868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}