{"id":"W4398193896","doi":"10.1016/j.jcyt.2024.03.047","title":"THERAPEUTIC GENOME EDITING FOR SEVERE MONOGENIC SKIN DISORDERS","year":2024,"lang":"en","type":"article","venue":"Cytotherapy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"","keywords":"Genome editing; Genetics; Biology; Medicine; Computational biology; Genome; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002384026,0.0004133616,0.0002860334,0.0003561973,0.0002206177,0.0004483415,0.0003311839,0.0005363889,0.002368536],"category_scores_gemma":[0.0001804026,0.0001378507,0.0003119144,0.0001772457,0.0003715133,0.0001866371,0.0004148611,0.001039421,0.0004623913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002539558,"about_ca_system_score_gemma":0.0002113511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002168507,"about_ca_topic_score_gemma":0.00038698,"domain_scores_codex":[0.9998251,0.00003764305,0.000009952162,0.00003808343,0.00006254883,0.00002676572],"domain_scores_gemma":[0.9998997,0.00002915746,0.00002588725,0.00002148391,0.000007532748,0.0000162809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001099321,0.00004206246,0.0001462967,0.0001204615,0.0000223915,0.0005432409,0.00003109048,0.0004360426,0.9778772,0.003120542,0.0005276164,0.01702313],"study_design_scores_gemma":[0.00004039963,0.0002584416,0.001298823,0.00004104429,0.0000598798,0.004179522,0.00003278092,0.001971822,0.9658154,0.001615943,0.02467032,0.00001560432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7274552,0.01907101,0.2154755,0.002161307,0.0008664113,0.000367618,0.001350891,0.002805571,0.03044647],"genre_scores_gemma":[0.9656055,0.004324505,0.02145683,0.0002643452,0.00003826208,0.00008641905,0.0003536297,0.000152916,0.007717693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002368536,"threshold_uncertainty_score":0.007923543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006766900999812881,"score_gpt":0.2933580132419752,"score_spread":0.2865911122421624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}