{"id":"W4398193903","doi":"10.1016/j.jcyt.2024.03.191","title":"IDENTIFICATION OF GENE REGULATORY NETWORKS ESSENTIAL FOR HEMATOPOIETIC PROGENITOR CELL AND T CELL EMERGENCE FROM HUMAN PLURIPOTENT STEM CELL VIA CRISPR SCREENS","year":2024,"lang":"en","type":"article","venue":"Cytotherapy","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"","keywords":"CRISPR; Induced pluripotent stem cell; Biology; Progenitor cell; Cell; Identification (biology); Stem cell; Gene; Haematopoiesis; Hematopoietic stem cell; Computational biology; Cell biology; Genetics; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001386786,0.0002000059,0.0001918602,0.00004143601,0.0001028636,0.00004604504,0.0001734303,0.0001972188,0.00001803476],"category_scores_gemma":[7.053725e-7,0.0002006176,0.000157337,0.00006768594,0.00008998907,0.000007418725,0.00001969273,0.00007619548,0.00000191781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001036676,"about_ca_system_score_gemma":0.00003563951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004121412,"about_ca_topic_score_gemma":0.00001388634,"domain_scores_codex":[0.9987211,0.00004126284,0.0004063682,0.0004925451,0.000124386,0.0002143576],"domain_scores_gemma":[0.9993662,0.0000131808,0.0001200292,0.0003470944,0.00007669193,0.00007679015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009074192,0.00016126,0.0001407458,0.000160894,0.00004406271,0.000001511366,0.0002609698,0.0001673707,0.9972239,0.00001425108,0.0005716181,0.001162662],"study_design_scores_gemma":[0.0005909951,0.000236569,0.0002074075,0.00002165788,0.00006384862,0.00000161306,0.00006271989,0.004806359,0.9925967,0.00007543615,0.001117779,0.0002188949],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7766379,0.01210276,0.2103056,0.00001847151,0.000422658,0.0004012852,0.00006781876,0.00002195698,0.00002155491],"genre_scores_gemma":[0.9969597,0.0006599618,0.0008690507,0.00004203931,0.0005282384,0.00005059356,0.0001591024,0.00006267986,0.0006686701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2203218,"threshold_uncertainty_score":0.8180949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00896466004140525,"score_gpt":0.2353068519838415,"score_spread":0.2263421919424363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}