{"id":"W4398194000","doi":"10.1016/j.jcyt.2024.04.051","title":"ENGINEERING CAR-EXPRESSING INNATE LYMPHOID CELLS (ILCS) FROM HUMAN PLURIPOTENT STEM CELLS (HPSCS) FOR CANCER IMMUNOTHERAPY","year":2024,"lang":"en","type":"article","venue":"Cytotherapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Paul's Hospital; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"","keywords":"Induced pluripotent stem cell; Innate lymphoid cell; Cancer immunotherapy; Biology; Immunotherapy; Cancer research; Immunology; Innate immune system; Immune system; Embryonic stem cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000446558,0.0005322722,0.0007296718,0.0003850969,0.0001685062,0.0003211862,0.0003700869,0.0002755962,0.002884259],"category_scores_gemma":[0.000003405792,0.0004811827,0.0004905891,0.0004125737,0.0001042366,0.0001832415,0.00004488182,0.0004578338,0.00006607828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008449621,"about_ca_system_score_gemma":0.0003186642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007243409,"about_ca_topic_score_gemma":0.00001839968,"domain_scores_codex":[0.9969473,0.00006961852,0.0006024205,0.0008914302,0.0006228369,0.0008663583],"domain_scores_gemma":[0.9983904,0.0002886034,0.00009151671,0.0008092865,0.0001570986,0.0002630506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005345609,0.000108116,0.0000883757,0.000258512,0.0007643186,0.00006965622,0.002015641,0.0005218126,0.915047,0.00005876485,0.00254072,0.07799254],"study_design_scores_gemma":[0.002722557,0.0002139492,0.00008338848,0.0005142752,0.00005106683,0.00001012058,0.00007834365,0.005649683,0.6455219,0.00006795421,0.3447312,0.0003555376],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9521996,0.03298963,0.007411436,0.000956571,0.002269434,0.002398429,0.0002962125,0.001103857,0.0003748559],"genre_scores_gemma":[0.9014995,0.01926821,0.005812232,0.003508165,0.006856235,0.002086177,0.0001677228,0.002093196,0.05870853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3421905,"threshold_uncertainty_score":0.999764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02884696111198442,"score_gpt":0.3121160642707506,"score_spread":0.2832691031587662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}