{"id":"W4398194063","doi":"10.1016/j.jcyt.2024.03.045","title":"DURABLE AND DOSE-DEPENDENT CORRECTION OF THE BIOCHEMICAL PHENOTYPE IN A MOUSE MODEL OF GUANIDINOACETATE METHYLTRANSFERASE (GAMT) CREATINE DEFICIENCY FOLLOWING TREATMENT WITH SCAAV9.HGAMT","year":2024,"lang":"en","type":"article","venue":"Cytotherapy","topic":"Health, Environment, Cognitive Aging","field":"Environmental Science","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Kingston Health Sciences Centre; Hospital for Sick Children; Queen's University","funders":"","keywords":"Creatine; Phenotype; Methyltransferase; Endocrinology; Internal medicine; Chemistry; Biochemistry; Medicine; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002524908,0.0006995168,0.0003813959,0.0008015606,0.0002534252,0.0003330752,0.0004686815,0.000710262,0.002405956],"category_scores_gemma":[0.0001646804,0.0001957592,0.0003572878,0.0002700038,0.0005000686,0.0002976623,0.0002297633,0.001342123,0.0005990406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002787247,"about_ca_system_score_gemma":0.0003480046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0013909,"about_ca_topic_score_gemma":0.003773934,"domain_scores_codex":[0.9997995,0.00002350609,0.00001998958,0.00005386358,0.00005825119,0.00004481724],"domain_scores_gemma":[0.9997281,0.00002101878,0.00008854295,0.00004056704,0.00003388494,0.0000879181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003299496,0.0002042241,0.0001691026,0.00004005779,0.00001401008,0.0001144123,0.00002260101,0.0001202844,0.9945394,0.000217581,0.000280441,0.003947912],"study_design_scores_gemma":[0.000151239,0.00269651,0.004261063,0.00002432746,0.00006142583,0.0004893278,0.00006037112,0.001105041,0.9862769,0.0001987221,0.004660915,0.00001430716],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9785397,0.002075827,0.009772116,0.0006579754,0.0002821137,0.0002087895,0.002344771,0.001517829,0.004600979],"genre_scores_gemma":[0.9759961,0.001279476,0.004949643,0.0001488605,0.00002528646,0.0001910632,0.001377259,0.0001373991,0.01589503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002405956,"threshold_uncertainty_score":0.008048654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01464522137589528,"score_gpt":0.2476128319621389,"score_spread":0.2329676105862437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}