{"id":"W4398194063","doi":"10.1016/j.jcyt.2024.03.045","title":"DURABLE AND DOSE-DEPENDENT CORRECTION OF THE BIOCHEMICAL PHENOTYPE IN A MOUSE MODEL OF GUANIDINOACETATE METHYLTRANSFERASE (GAMT) CREATINE DEFICIENCY FOLLOWING TREATMENT WITH SCAAV9.HGAMT","year":2024,"lang":"en","type":"article","venue":"Cytotherapy","topic":"Health, Environment, Cognitive Aging","field":"Environmental Science","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Kingston Health Sciences Centre; Hospital for Sick Children; Queen's University","funders":"","keywords":"Creatine; Phenotype; Methyltransferase; Endocrinology; Internal medicine; Chemistry; Biochemistry; Medicine; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003260084,0.0001759149,0.0002247205,0.00005439764,0.00006569983,0.00001493426,0.0001059009,0.00005583483,0.00008750569],"category_scores_gemma":[0.00001107677,0.0001143811,0.00006720805,0.0002413876,0.0001766352,0.0001357029,0.00002656171,0.0001215228,0.00000601081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002961418,"about_ca_system_score_gemma":0.00004365601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001039801,"about_ca_topic_score_gemma":0.0001754347,"domain_scores_codex":[0.9986945,0.0000951932,0.0002693593,0.0004205899,0.0002831511,0.0002371822],"domain_scores_gemma":[0.9995438,0.00009446953,0.00005382226,0.0002454544,0.000003991245,0.00005848795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009986688,0.0002023457,0.01783402,0.00002787949,0.0000286603,0.000003746485,0.002713413,0.01104162,0.9527145,0.00001896773,0.000003973869,0.01531101],"study_design_scores_gemma":[0.001646294,0.0004352273,0.009278092,0.0001459001,0.00005770724,0.000005829278,0.0003731224,0.06831197,0.9192744,0.0002221982,0.0000339073,0.0002153894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941422,0.0005548846,0.00374504,0.0001218047,0.00004856199,0.0005258829,0.00001524363,0.00002323835,0.000823125],"genre_scores_gemma":[0.9980947,0.0007377774,0.0006488419,0.00006129995,0.000005970745,0.00004375782,0.000001603266,0.00003014635,0.0003758577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05727035,"threshold_uncertainty_score":0.4664326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01464522137589528,"score_gpt":0.2476128319621389,"score_spread":0.2329676105862437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}