{"id":"W4398198887","doi":"10.1016/j.jcyt.2024.03.424","title":"LIPID NANOPARTICLES ENABLE EFFICIENT BASE EDITING OF CD45-DIRECTED CAR T CELLS FOR UNIVERSAL BLOOD CANCER IMMUNOTHERAPY","year":2024,"lang":"en","type":"article","venue":"Cytotherapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Precision Nanosystems (Canada)","funders":"","keywords":"Cancer immunotherapy; Immunotherapy; Base (topology); Cancer; Cancer research; Medicine; Internal medicine; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001808271,0.0003167855,0.0001816348,0.0001234428,0.0001454663,0.0004623854,0.0001900169,0.0004174484,0.001124055],"category_scores_gemma":[0.0001676764,0.0001693463,0.0001667006,0.00009690006,0.0002045166,0.0002649712,0.0004084942,0.000530399,0.0005038801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002996935,"about_ca_system_score_gemma":0.0001766245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003125372,"about_ca_topic_score_gemma":0.000514568,"domain_scores_codex":[0.9998662,0.00001947021,0.000007144463,0.00003139229,0.00004018436,0.00003560963],"domain_scores_gemma":[0.9999341,0.00001437232,0.00001967237,0.00001031911,0.00001205117,0.000009484142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003697289,0.000008734532,0.00003805936,0.0000196757,0.000002585057,0.00002952243,0.00001977558,0.0001341007,0.9963422,0.0007150818,0.00007540261,0.002577864],"study_design_scores_gemma":[0.000004745567,0.00002772031,0.00006109718,0.000001498218,0.000004295627,0.00004411574,0.000005045669,0.0006980457,0.9973382,0.0000661502,0.001747098,0.000001997646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.904624,0.001692875,0.08410002,0.000402468,0.000118071,0.0001364115,0.000251726,0.0007462805,0.007928097],"genre_scores_gemma":[0.9851283,0.0004047527,0.01057656,0.00007757339,0.000007938349,0.00003824621,0.00009744741,0.00007264032,0.003596492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001124055,"threshold_uncertainty_score":0.003760338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009737023033002869,"score_gpt":0.2486114413601319,"score_spread":0.238874418327129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}