{"id":"W4398198889","doi":"10.1016/j.jcyt.2024.03.374","title":"INCREASED TRANSFECTION OF T AND NK CELLS WITH MRNA LIPID NANOPARTICLES FOR CELLULAR IMMUNOTHERAPIES","year":2024,"lang":"en","type":"article","venue":"Cytotherapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"","keywords":"Transfection; Messenger RNA; Cell biology; Chemistry; Molecular biology; Biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003162908,0.0001601385,0.0002989833,0.0001639981,0.00005523716,0.00004539707,0.00005646888,0.00007747883,0.000699332],"category_scores_gemma":[0.000004661752,0.0001179955,0.0001094432,0.0002424586,0.0001856558,0.00007748831,0.000004156503,0.0001178014,0.000005078745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000425874,"about_ca_system_score_gemma":0.0001025995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001089231,"about_ca_topic_score_gemma":0.00001616398,"domain_scores_codex":[0.9990178,0.00004882297,0.0002050748,0.0002698115,0.0002228128,0.0002357077],"domain_scores_gemma":[0.999397,0.0001833961,0.00002493402,0.0002316002,0.00007916763,0.00008392358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002879521,0.0001140102,0.0004067002,0.0004737968,0.0003116858,0.000009662407,0.001266128,0.000005913509,0.9454387,0.0001780065,0.0001123236,0.04880349],"study_design_scores_gemma":[0.003203699,0.00210858,0.0003128777,0.0002350478,0.00006229437,0.00002747627,0.0001346741,0.0009408836,0.9684151,0.0001623331,0.0242686,0.0001284522],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879146,0.007715158,0.002508079,0.0004593386,0.00008309932,0.0009556257,0.00001983564,0.0001006372,0.0002436407],"genre_scores_gemma":[0.9948812,0.002223681,0.0008381332,0.0001308734,0.0001945829,0.00009973727,0.000008561648,0.00008149831,0.001541707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04867504,"threshold_uncertainty_score":0.7657195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0178747126830854,"score_gpt":0.2813582223888962,"score_spread":0.2634835097058108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}