{"id":"W4398198889","doi":"10.1016/j.jcyt.2024.03.374","title":"INCREASED TRANSFECTION OF T AND NK CELLS WITH MRNA LIPID NANOPARTICLES FOR CELLULAR IMMUNOTHERAPIES","year":2024,"lang":"en","type":"article","venue":"Cytotherapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"","keywords":"Transfection; Messenger RNA; Cell biology; Chemistry; Molecular biology; Biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001799,0.0003188207,0.0002746261,0.0001550405,0.0001642695,0.000446704,0.0001533273,0.0004330802,0.001509039],"category_scores_gemma":[0.0001972418,0.0001136235,0.0002165781,0.0001390735,0.0002888878,0.0003137531,0.0002573973,0.0005860262,0.0004431783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004126832,"about_ca_system_score_gemma":0.0002709352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004890152,"about_ca_topic_score_gemma":0.0006082628,"domain_scores_codex":[0.9998081,0.00002883602,0.00001388912,0.00004859245,0.0000556218,0.00004480869],"domain_scores_gemma":[0.9999179,0.00002554201,0.00001840427,0.000009626689,0.00001871697,0.000009886184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006251427,0.00001991097,0.00006009026,0.00004381309,0.000003882463,0.00002506534,0.00002208937,0.0001390637,0.9968017,0.0003087704,0.00005078101,0.002462242],"study_design_scores_gemma":[0.000006707729,0.00009114263,0.0001928604,0.000002372823,0.00001153172,0.00003746816,0.000008564577,0.0005063781,0.9976333,0.00003432839,0.001473184,0.000002116439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9670757,0.001965044,0.02570487,0.000261558,0.0001443059,0.00008859611,0.0001833042,0.0003048195,0.004271756],"genre_scores_gemma":[0.9883819,0.0006817282,0.006933748,0.00007439694,0.00001675785,0.00007627591,0.0001471839,0.00005357492,0.003634578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001509039,"threshold_uncertainty_score":0.005048215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0178747126830854,"score_gpt":0.2813582223888962,"score_spread":0.2634835097058108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}