{"id":"W4398198890","doi":"10.1016/j.jcyt.2024.03.339","title":"THYMUS-DERIVED REGULATORY T CELLS AS A UNIVERSAL OFF-THE-SHELF ANTI-INFLAMMATORY THERAPY: TECHNOLOGY TRANSFER IN PREPARATION FOR A PHASE I CLINICAL TRIAL","year":2024,"lang":"en","type":"article","venue":"Cytotherapy","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; University of Alberta; University of British Columbia; BC Children's Hospital","funders":"","keywords":"Off the shelf; Clinical trial; Phase (matter); Medicine; Immunology; Chemistry; Internal medicine; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003413313,0.0006394269,0.000997178,0.0003420603,0.00033909,0.001614334,0.0007905486,0.002020391,0.00413539],"category_scores_gemma":[0.001373269,0.0001976336,0.001196206,0.0002628566,0.000813895,0.0007893705,0.0005777205,0.003814253,0.0008983432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005799275,"about_ca_system_score_gemma":0.001375552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002898799,"about_ca_topic_score_gemma":0.0003899576,"domain_scores_codex":[0.9991309,0.0004270255,0.00003390047,0.0001009446,0.0001117627,0.0001954972],"domain_scores_gemma":[0.9994057,0.0001365249,0.000102285,0.00009299436,0.00007440762,0.000187986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.1217492,0.04725107,0.003352352,0.001976704,0.0007257095,0.0004781609,0.0008573424,0.00414179,0.2437404,0.007072576,0.01058698,0.5580678],"study_design_scores_gemma":[0.0915451,0.7125024,0.006509761,0.0007736097,0.00114632,0.0008175429,0.0004634185,0.00351,0.1206893,0.003948078,0.05802108,0.00007352758],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9487635,0.0197394,0.0118854,0.00296045,0.001485405,0.006253212,0.0008565806,0.0003464428,0.007709695],"genre_scores_gemma":[0.9677901,0.008548702,0.01148084,0.002634311,0.0003456988,0.00308727,0.001175368,0.00007861356,0.004859246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00413539,"threshold_uncertainty_score":0.01805156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.042339644382727,"score_gpt":0.3775475929284715,"score_spread":0.3352079485457444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}