{"id":"W4398198890","doi":"10.1016/j.jcyt.2024.03.339","title":"THYMUS-DERIVED REGULATORY T CELLS AS A UNIVERSAL OFF-THE-SHELF ANTI-INFLAMMATORY THERAPY: TECHNOLOGY TRANSFER IN PREPARATION FOR A PHASE I CLINICAL TRIAL","year":2024,"lang":"en","type":"article","venue":"Cytotherapy","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; University of Alberta; University of British Columbia; BC Children's Hospital","funders":"","keywords":"Off the shelf; Clinical trial; Phase (matter); Medicine; Immunology; Chemistry; Internal medicine; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001257187,0.0002412321,0.0004660389,0.0002263362,0.0001243837,0.00003601329,0.0003055192,0.0008200236,0.0003992284],"category_scores_gemma":[0.00004337769,0.0001652915,0.0003449995,0.0003164526,0.0006425167,0.00008741915,0.00001788208,0.0004857534,0.00005158276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004896753,"about_ca_system_score_gemma":0.000244674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000444958,"about_ca_topic_score_gemma":0.00001235932,"domain_scores_codex":[0.997947,0.0004884474,0.0006037474,0.0005392669,0.00004743804,0.0003741201],"domain_scores_gemma":[0.9989021,0.0005696822,0.0000529581,0.0003961945,0.0000506062,0.0000284586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.03127156,0.0005511775,0.00002847332,0.00001750966,0.0004330137,0.0000159732,0.0004618483,0.000001224473,0.7600247,0.005777695,0.001374891,0.200042],"study_design_scores_gemma":[0.04929923,0.003869148,0.00006535656,0.00004338879,0.00006168784,0.00001494048,0.0001677309,0.0001674113,0.4304747,0.001816089,0.5137505,0.0002698815],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9741668,0.01513373,0.003263915,0.003285645,0.001815003,0.001934006,0.000042095,0.0002055338,0.000153326],"genre_scores_gemma":[0.9901226,0.005724148,0.0004690014,0.001260072,0.0003136417,0.0002095693,0.00002513411,0.00006133562,0.001814562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5123756,"threshold_uncertainty_score":0.674039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.042339644382727,"score_gpt":0.3775475929284715,"score_spread":0.3352079485457444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}