{"id":"W4398199060","doi":"10.1016/j.jcyt.2024.03.035","title":"SINGLE-DOSE GLP-1-BASED PANCREATIC GENE THERAPY PRODUCES SUSTAINED LOWERING OF BLOOD GLUCOSE AND BODY WEIGHT IN MURINE MODELS OF DIABETES AND OBESITY","year":2024,"lang":"en","type":"article","venue":"Cytotherapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Cell biology; Chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000436738,0.001041937,0.0007378268,0.001403991,0.0003485619,0.0007550141,0.0005863464,0.001104511,0.001941881],"category_scores_gemma":[0.0001899234,0.0003844353,0.0007632039,0.0005135973,0.001007501,0.0006522608,0.0002845915,0.00343113,0.000530686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005900926,"about_ca_system_score_gemma":0.0005345505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006952198,"about_ca_topic_score_gemma":0.001429562,"domain_scores_codex":[0.9995824,0.00004982712,0.00003124225,0.0001084449,0.0001132516,0.0001149719],"domain_scores_gemma":[0.9995465,0.0000432836,0.0001716511,0.00004315541,0.00002593631,0.0001693337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001102835,0.000439826,0.0001134705,0.00004698162,0.00001230745,0.00004097794,0.00002824011,0.0002858377,0.9948136,0.0003551559,0.0001655994,0.002595341],"study_design_scores_gemma":[0.0001753255,0.002056811,0.000906262,0.00001480882,0.00003550823,0.00007755614,0.00004081998,0.001355825,0.9938181,0.0001317093,0.001375169,0.00001197319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790028,0.001717504,0.0123567,0.0007641017,0.0003982127,0.0001623154,0.001725231,0.000823012,0.003050257],"genre_scores_gemma":[0.9770355,0.001581046,0.009843745,0.000301162,0.0001015732,0.0003058419,0.001214091,0.0002696189,0.009347432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001941881,"threshold_uncertainty_score":0.006496251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02040176216693964,"score_gpt":0.2706935016785609,"score_spread":0.2502917395116213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}