{"id":"W4398199738","doi":"10.1126/scitranslmed.adj3385","title":"Integrated analysis of blood DNA methylation, genetic variants, circulating proteins, microRNAs, and kidney failure in type 1 diabetes","year":2024,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; Leona M. and Harry B. Helmsley Charitable Trust; Novo Nordisk Fonden; Samfundet Folkhälsan; Queen's University; National Institutes of Health; Wilhelm och Else Stockmanns Stiftelse; McKnight Foundation; Folkhälsanin Tutkimussäätiö; Helsingin ja Uudenmaan Sairaanhoitopiiri; Novo Nordisk","keywords":"DNA methylation; Medicine; White blood cell; Genetic variation; Internal medicine; Type 2 diabetes; Diabetes mellitus; Bioinformatics; Biology; Oncology; Endocrinology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002106339,0.0005227081,0.000571676,0.0004063118,0.0001907251,0.000587056,0.000350119,0.0003346379,0.0005769501],"category_scores_gemma":[0.002734447,0.0002263839,0.0006937271,0.0005127009,0.0001211816,0.0002225884,0.0003668582,0.0007055609,0.0001263705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004262268,"about_ca_system_score_gemma":0.0005611312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01176014,"about_ca_topic_score_gemma":0.01077699,"domain_scores_codex":[0.9995308,0.0002162699,0.0000230033,0.0001523944,0.00004683901,0.00003074591],"domain_scores_gemma":[0.9988878,0.0006417351,0.0001855231,0.00009365461,0.00009910046,0.00009223605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001732531,0.0001406157,0.9448963,0.0000456287,0.001326499,0.00009933298,0.00006787552,0.02014153,0.005117139,0.00008630331,0.0003300774,0.02601619],"study_design_scores_gemma":[0.00007193649,0.000529209,0.6989335,0.00002112663,0.0009892952,0.0001831587,0.00006453033,0.2949731,0.003033873,0.0007064745,0.0004615143,0.0000323872],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914922,0.0005145392,0.006971,0.0001014123,0.00001075667,0.00001044704,0.0005957715,0.00007044207,0.0002334053],"genre_scores_gemma":[0.9970272,0.000103676,0.002238548,0.00002648523,0.000006806149,0.000007490407,0.0004416021,0.000007003126,0.000141146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01176014,"threshold_uncertainty_score":0.02338338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0107777741137536,"score_gpt":0.2662561822822846,"score_spread":0.2554784081685311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}