{"id":"W4398204388","doi":"10.3390/ijms25115625","title":"Differences in Metabolite Profiles of Dihydroberberine and Micellar Berberine in Caco-2 Cells and Humans—A Pilot Study","year":2024,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Berberine and alkaloids research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Burnaby Hospital","funders":"","keywords":"Berberine; Jatrorrhizine; Metabolite; Chemistry; Pharmacology; In vivo; Pharmacokinetics; Glucuronide; Active metabolite; In vitro; Biochemistry; Chromatography; Palmatine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005795631,0.0003240556,0.0005217253,0.0001747223,0.0002092654,0.0003373969,0.0001603061,0.0005737596,0.001708958],"category_scores_gemma":[0.0005498724,0.000217282,0.0002584388,0.0001633538,0.0003008523,0.0002798692,0.000180437,0.0004572433,0.0004176881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002414318,"about_ca_system_score_gemma":0.0002104024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000874162,"about_ca_topic_score_gemma":0.001281069,"domain_scores_codex":[0.9997196,0.0001143305,0.00001465314,0.00008194407,0.00004909113,0.00002040481],"domain_scores_gemma":[0.999826,0.00003374716,0.00004723131,0.00002742568,0.00002701305,0.00003861552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.05867621,0.006228852,0.01099519,0.0006391337,0.0003053401,0.0003868091,0.000325376,0.0001902957,0.8887786,0.00009395754,0.000701219,0.03267897],"study_design_scores_gemma":[0.009604701,0.3702515,0.2066046,0.00006683025,0.001284301,0.003356718,0.0006231751,0.001962947,0.3843079,0.0001322917,0.02173229,0.00007281102],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961532,0.001793605,0.0006962122,0.00008237868,0.00002914363,0.0002791399,0.000302627,0.00002522068,0.0006385385],"genre_scores_gemma":[0.9953779,0.000908696,0.001506775,0.0002066769,0.00002798997,0.0001993602,0.0004122068,0.00001591667,0.001344467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001708958,"threshold_uncertainty_score":0.005717039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03421291415214976,"score_gpt":0.3442007393547415,"score_spread":0.3099878252025918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}