{"id":"W4398220378","doi":"10.1101/2024.05.20.24307583","title":"A Natural History Study of Timothy Syndrome","year":2024,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Natural history; Natural (archaeology); History; Archaeology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002711805,0.0002126036,0.0001729402,0.0009140357,0.0008936441,0.0003503325,0.0001852051,0.0005186301,0.001527014],"category_scores_gemma":[0.00164447,0.0001196273,0.0001711802,0.0003316129,0.0004102238,0.0004401502,0.0005248621,0.0004469706,0.0002616225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003403774,"about_ca_system_score_gemma":0.0002419595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00188149,"about_ca_topic_score_gemma":0.0009858758,"domain_scores_codex":[0.9997646,0.00006443002,0.00001343946,0.00006722094,0.00004935641,0.00004093699],"domain_scores_gemma":[0.9991817,0.0002344578,0.0001475281,0.00005301847,0.0001086678,0.000274576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004150764,0.0003717364,0.8912091,0.00003979754,0.00002475199,0.07858725,0.00365685,0.0001484091,0.007216305,0.001122282,0.003041513,0.01416691],"study_design_scores_gemma":[0.00002491727,0.0008243245,0.7835518,0.00005060022,0.00003793209,0.2028462,0.001851431,0.0006803678,0.001550793,0.0009316453,0.007607125,0.00004290243],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966649,0.0002451539,0.0002932986,0.0003254049,0.00001442689,0.00002615037,0.0003003282,0.00001085565,0.002119466],"genre_scores_gemma":[0.9980719,0.0002207374,0.0003458,0.0002467569,0.00003903852,0.00001660245,0.0003225227,0.000008021502,0.0007286293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00188149,"threshold_uncertainty_score":0.005108356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01823002865394202,"score_gpt":0.2504847159022763,"score_spread":0.2322546872483343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}