{"id":"W4398224649","doi":"10.1016/j.imlet.2024.106870","title":"The Th1/Th2 paradigm: A misrepresentation of helper T cell plasticity","year":2024,"lang":"en","type":"review","venue":"Immunology Letters","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Canada Research Chairs","keywords":"Misrepresentation; Context (archaeology); Paradigm shift; T helper cell; Biology; T cell; Mass cytometry; Cognitive science; Neuroscience; Immune system; Immunology; Psychology; Epistemology; Genetics; Political science; Phenotype; Philosophy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001433738,0.0007561215,0.001134763,0.001591912,0.0004126207,0.001368127,0.00126837,0.001627775,0.00178004],"category_scores_gemma":[0.001241577,0.0002307352,0.0002665579,0.001394501,0.001779047,0.002575106,0.001001109,0.003914184,0.002096619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001191058,"about_ca_system_score_gemma":0.001273059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006730509,"about_ca_topic_score_gemma":0.0009158795,"domain_scores_codex":[0.9996673,0.00008715452,0.00003132312,0.00006016321,0.0001233925,0.00003070328],"domain_scores_gemma":[0.9992453,0.0003757663,0.00006002745,0.00003381045,0.0002072699,0.00007784422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.00008429569,0.00003113196,0.0002068423,0.006817453,0.00004836965,0.0003327027,0.0001363747,0.0003476191,0.002116884,0.0305497,0.08766369,0.8716651],"study_design_scores_gemma":[0.00000796816,0.00004242334,0.0003570919,0.001481188,0.00002168476,0.001170919,0.0000926042,0.00008404854,0.0003014916,0.0108011,0.985624,0.00001565503],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009866153,0.9944835,0.000377312,0.002230596,0.001695183,0.000001644971,0.000006999577,0.00001133688,0.001094743],"genre_scores_gemma":[0.00141407,0.9932227,0.000320596,0.001463623,0.002631327,0.000005441883,0.00001380113,0.00000431553,0.0009240735],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00178004,"threshold_uncertainty_score":0.008641839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02225428785178269,"score_gpt":0.2751533218618863,"score_spread":0.2528990340101037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}