{"id":"W4398228767","doi":"10.1016/j.jcyt.2024.04.058","title":"MULTI GENE EDITING OF IPSCS WITH NOVEL TRANSFECTION PLATFORM SOLUPORE® FOR GENERATION OF EFFICIENTLY EDITED AND HEALTHY IPSC LINES.","year":2024,"lang":"en","type":"article","venue":"Cytotherapy","topic":"Transgenic Plants and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Regenerative Medicine","funders":"","keywords":"Induced pluripotent stem cell; Transfection; Genome editing; Computational biology; Gene; Biology; Genetics; CRISPR; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007235004,0.0005383829,0.0004338136,0.0006468805,0.0003575507,0.0005725987,0.0005535447,0.0006447561,0.002510753],"category_scores_gemma":[0.0003009312,0.000365522,0.0004862864,0.0003042749,0.0003501597,0.000372646,0.0006785049,0.001253466,0.001147283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002776887,"about_ca_system_score_gemma":0.0003476201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002600927,"about_ca_topic_score_gemma":0.0005948013,"domain_scores_codex":[0.9995874,0.00004849895,0.0000409666,0.0001042233,0.0001704292,0.00004849895],"domain_scores_gemma":[0.999813,0.00004733711,0.00004490353,0.00003299153,0.0000346893,0.00002707362],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002592181,0.00001495425,0.00004407082,0.00007846192,0.000007069671,0.00006084075,0.00003374534,0.0001021714,0.9940639,0.0004214654,0.0002773698,0.004870007],"study_design_scores_gemma":[0.00001069034,0.00007476764,0.0003414766,0.00001694504,0.00002601076,0.0003848638,0.000009241277,0.001073971,0.9869735,0.0001227707,0.01095507,0.00001059647],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4847955,0.00802627,0.4709415,0.0006362881,0.0007290718,0.0009419633,0.003765256,0.005708196,0.02445599],"genre_scores_gemma":[0.7186896,0.00503095,0.2347943,0.0003601486,0.0001033492,0.001173795,0.007384672,0.001172476,0.03129083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002510753,"threshold_uncertainty_score":0.008399308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03947574370168606,"score_gpt":0.2914453791838831,"score_spread":0.2519696354821971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}