{"id":"W4398239062","doi":"10.3390/metabo14060295","title":"Metabolites Associated with Polygenic Risk of Breast Cancer","year":2024,"lang":"en","type":"article","venue":"Metabolites","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Breast cancer; Cancer; Single-nucleotide polymorphism; Internal medicine; Medicine; Oncology; Biology; Bioinformatics; Physiology; Endocrinology; Genotype; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003639738,0.0002969954,0.0004612374,0.0001364475,0.00007063089,0.00005801089,0.0002342129,0.0001561359,0.0002087591],"category_scores_gemma":[0.0001245093,0.0002221278,0.0002721987,0.0004608756,0.0001776558,0.00001493623,0.00007767689,0.0001686957,0.00001083513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001500548,"about_ca_system_score_gemma":0.0002837386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004793915,"about_ca_topic_score_gemma":0.0002696415,"domain_scores_codex":[0.9983178,0.0001446133,0.0003333787,0.0005169008,0.0002719756,0.0004152672],"domain_scores_gemma":[0.9990378,0.00004857217,0.0001453322,0.0004271267,0.0002129088,0.0001282368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002481702,0.0001708533,0.04934662,0.0001161194,0.002668675,5.33053e-7,0.0002832582,0.00009205386,0.906573,0.002136166,0.01556575,0.02279881],"study_design_scores_gemma":[0.0008227618,0.00007875328,0.1947401,0.00009851268,0.001207461,0.00002114843,0.00008788944,0.00007840947,0.1471053,0.0002113982,0.6550877,0.0004606176],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7734366,0.2189175,0.0002222396,0.0001426054,0.004259456,0.0002106523,0.002069564,0.00006903299,0.0006723468],"genre_scores_gemma":[0.9725693,0.01513199,0.0003203166,0.0001402236,0.008093025,0.00008772112,0.0001799838,0.00007899675,0.00339845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7594677,"threshold_uncertainty_score":0.9058109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005808220217426174,"score_gpt":0.2382115989832621,"score_spread":0.2324033787658359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}