{"id":"W4398240584","doi":"10.1038/s41467-024-48555-z","title":"Development of a nucleoside-modified mRNA vaccine against clade 2.3.4.4b H5 highly pathogenic avian influenza virus","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; University of Pennsylvania; U.S. Department of Health and Human Services","keywords":"Virology; Hemagglutinin (influenza); Virus; Antibody; Influenza A virus subtype H5N1; Biology; Highly pathogenic; Vaccination; Pandemic; Messenger RNA; Influenza A virus; Microbiology; Gene; Medicine; Immunology; Coronavirus disease 2019 (COVID-19); Infectious disease (medical specialty); Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008448227,0.0002011687,0.0001153082,0.00007624718,0.00007829419,0.000133827,0.0001268751,0.0002490864,0.0007559093],"category_scores_gemma":[0.00007784719,0.00006430703,0.0001394171,0.0000304166,0.0001151878,0.000126158,0.00011873,0.0002482445,0.0002225963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001957919,"about_ca_system_score_gemma":0.0001694482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003385493,"about_ca_topic_score_gemma":0.0005174088,"domain_scores_codex":[0.9999601,0.000006684762,0.000002483838,0.000009163988,0.00001356581,0.000008023429],"domain_scores_gemma":[0.9999735,0.000003827813,0.000009643424,0.000002079186,0.0000051825,0.000005744245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000234573,0.00002323521,0.00009531697,0.00002864119,0.000002478652,0.00002145185,0.00000539956,0.000184799,0.9963666,0.00008379299,0.00003876698,0.003126112],"study_design_scores_gemma":[0.00002168583,0.001415439,0.001175055,0.00001020872,0.00001685054,0.0001750281,0.00001910839,0.001884731,0.9908528,0.00005918259,0.004365399,0.000004398808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9747347,0.00134403,0.01967285,0.0002615103,0.00009333227,0.0001439851,0.0001568542,0.00009754375,0.003495202],"genre_scores_gemma":[0.9769216,0.0009703508,0.01766043,0.0001200682,0.00002119028,0.00006972453,0.0003370152,0.00001583449,0.003883709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007559093,"threshold_uncertainty_score":0.002528787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08041937460137728,"score_gpt":0.4011133963798518,"score_spread":0.3206940217784745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}