{"id":"W4398240584","doi":"10.1038/s41467-024-48555-z","title":"Development of a nucleoside-modified mRNA vaccine against clade 2.3.4.4b H5 highly pathogenic avian influenza virus","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; University of Pennsylvania; U.S. Department of Health and Human Services","keywords":"Virology; Hemagglutinin (influenza); Virus; Antibody; Influenza A virus subtype H5N1; Biology; Highly pathogenic; Vaccination; Pandemic; Messenger RNA; Influenza A virus; Microbiology; Gene; Medicine; Immunology; Coronavirus disease 2019 (COVID-19); Infectious disease (medical specialty); Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005167126,0.0002937205,0.0004992005,0.0005107365,0.0004532883,0.00005344892,0.00101481,0.0004098318,0.0000369166],"category_scores_gemma":[0.001065754,0.000250001,0.0002045871,0.001058316,0.0001910792,0.0001223236,0.0009416477,0.002172199,0.0001966929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003503613,"about_ca_system_score_gemma":0.000717812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003670679,"about_ca_topic_score_gemma":0.0006021384,"domain_scores_codex":[0.9976095,0.0001482577,0.0008140979,0.0003666484,0.0006197742,0.0004417157],"domain_scores_gemma":[0.9962114,0.0004510532,0.0001308066,0.002350214,0.0006561925,0.0002003053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006941931,0.00159022,0.005768835,0.0013676,0.003093292,0.00008788779,0.01132748,0.00004117403,0.7971441,0.04226003,0.03351934,0.1031059],"study_design_scores_gemma":[0.001299259,0.00008385903,0.05819508,0.000738711,0.000183947,0.00001093625,0.0002605714,0.0006206508,0.01804882,0.0001441686,0.9200858,0.0003281805],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7261912,0.218253,0.00009526505,0.01020242,0.0006906654,0.002571594,0.0003580602,0.0009641053,0.04067374],"genre_scores_gemma":[0.9711669,0.003632691,0.02221705,0.002230197,0.0001176264,0.0001997532,0.0001535757,0.00006480573,0.0002173799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8865665,"threshold_uncertainty_score":0.9999952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08041937460137728,"score_gpt":0.4011133963798518,"score_spread":0.3206940217784745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}