{"id":"W4398251506","doi":"10.1016/j.jbc.2024.107407","title":"Splice variants of CK1α and CK1α-like: Comparative analysis of subcellular localization, kinase activity, and function in the Wnt signaling pathway","year":2024,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Genentech; Grantová Agentura České Republiky; Ministerstvo Školství, Mládeže a Tělovýchovy; Deutsche Forschungsgemeinschaft; Deutschen Konsortium für Translationale Krebsforschung; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Ontario Genomics; Genome Canada; McGill University; Bayer; European Commission; Pfizer; Deutsches Krebsforschungszentrum; Bristol-Myers Squibb","keywords":"Wnt signaling pathway; Casein kinase 1; Function (biology); Cell biology; Subcellular localization; Signal transduction; Kinase; Computational biology; Biology; Protein kinase A; Cytoplasm","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002306945,0.0003415773,0.0002576274,0.0003391922,0.0001711559,0.0003530254,0.0002435903,0.0002197777,0.0008257877],"category_scores_gemma":[0.0002099101,0.0001334793,0.000341767,0.0003274419,0.000213878,0.0001771089,0.000152077,0.0004428576,0.0003989342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003078775,"about_ca_system_score_gemma":0.0001286476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004996167,"about_ca_topic_score_gemma":0.0006571656,"domain_scores_codex":[0.9997867,0.00002727283,0.00004015891,0.00004376992,0.00006292695,0.00003918216],"domain_scores_gemma":[0.9997842,0.00003604798,0.00006507356,0.00002477718,0.00002936182,0.00006067363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001467687,0.00001593207,0.000204252,0.00001879528,0.000006633486,0.00005051028,0.00001158699,0.00004044917,0.9989304,0.0000605078,0.00001588037,0.0004982268],"study_design_scores_gemma":[0.00002037272,0.0002547916,0.009233857,0.000007392951,0.00006499841,0.001250289,0.0000539376,0.001062577,0.9844757,0.00005586922,0.003510025,0.00001009762],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930868,0.001906497,0.003292732,0.00005118709,0.00003817285,0.00003852916,0.0008089973,0.00002752345,0.0007495557],"genre_scores_gemma":[0.9881909,0.001701454,0.004028958,0.00005515284,0.00001921023,0.00006228412,0.003533716,0.00005736853,0.002351132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008257877,"threshold_uncertainty_score":0.002762556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02455442104140131,"score_gpt":0.2626475640704757,"score_spread":0.2380931430290744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}