{"id":"W4398251954","doi":"10.1093/ndt/gfae069.716","title":"#2267 IL-33 Inhibition with tozorakimab for diabetic kidney disease: a randomized, placebo-controlled phase 2b study","year":2024,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Placebo; Medicine; Internal medicine; Phase (matter); Randomized controlled trial; Chemistry; Alternative medicine; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002305078,0.00160373,0.002947068,0.0005265172,0.0006010197,0.00115,0.000792674,0.00207966,0.009352135],"category_scores_gemma":[0.001448146,0.0006971795,0.002030894,0.0004623058,0.00115944,0.0009873125,0.0003594041,0.002328797,0.001380729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005267637,"about_ca_system_score_gemma":0.00156123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006573776,"about_ca_topic_score_gemma":0.001442299,"domain_scores_codex":[0.9992691,0.0003816143,0.00005266942,0.0001141665,0.00006227662,0.0001202155],"domain_scores_gemma":[0.9991291,0.0002023698,0.0001874232,0.00006008507,0.0001026115,0.0003182516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9715706,0.01107874,0.0003785419,0.000786211,0.0008321861,0.00002943674,0.00002455561,0.0001721541,0.004104119,0.00007761814,0.0009458712,0.0100001],"study_design_scores_gemma":[0.9479862,0.05010716,0.0007250032,0.00002314491,0.0002718963,0.00001385752,0.000008240091,0.0001410792,0.0002320882,0.00004804672,0.0004351746,0.000008081753],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9596919,0.009279173,0.001690537,0.001557187,0.001184886,0.02000235,0.003003977,0.0002874319,0.003302565],"genre_scores_gemma":[0.9634052,0.005026703,0.003328913,0.002801447,0.001011896,0.01771121,0.001733163,0.00004117979,0.004940258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009352135,"threshold_uncertainty_score":0.03128606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008055155863904014,"score_gpt":0.2479530375349654,"score_spread":0.2398978816710614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}