{"id":"W4398255666","doi":"10.1017/cjn.2024.267","title":"Health Canada Drug Approval Process: A Barrier to Personalized Care in Multiple Sclerosis","year":2024,"lang":"en","type":"article","venue":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Memorial University of Newfoundland; Montreal Neurological Institute and Hospital; Health Sciences Centre; Ottawa Hospital; London Health Sciences Centre; Université Laval; University of Saskatchewan; St. Michael's Hospital; Sunnybrook Health Science Centre; Hotchkiss Brain Institute; University of British Columbia; University of Calgary","funders":"EMD Serono; University of Toronto; Saskatchewan Health Research Foundation; Horizon Therapeutics; Atara Biotherapeutics; Celgene; Biogen; Saskatoon City Hospital Foundation; Alexion Pharmaceuticals; Teva Pharmaceutical Industries; Bayer HealthCare; Sanofi; Amgen; Pfizer; Ontario Medical Association; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Multiple sclerosis; Expanded access; Drug; Process (computing); Medicine; Internet privacy; Computer science; Pharmacology; Oncology; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.05025602,0.0003011898,0.0008606603,0.002565189,0.006856277,0.00965992,0.003179789,0.005984359,0.02477032],"category_scores_gemma":[0.2398895,0.0007015985,0.001227886,0.004551302,0.003079134,0.003275343,0.003030339,0.01043533,0.001754364],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.06306617,"about_ca_system_score_gemma":0.1908121,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9024384,"about_ca_topic_score_gemma":0.934664,"domain_scores_codex":[0.9299358,0.02024468,0.004826306,0.002856747,0.035262,0.006874541],"domain_scores_gemma":[0.696146,0.1996293,0.01737254,0.006870464,0.05580518,0.02417662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003073205,0.0001969404,0.03800553,0.0009268689,0.0001860583,0.0007777823,0.003512687,0.001574788,0.0004394562,0.05865853,0.6557838,0.2396302],"study_design_scores_gemma":[0.0004488037,0.0002730889,0.2206716,0.005246989,0.0003385348,0.001401086,0.003448385,0.006300607,0.001132954,0.02440433,0.7359805,0.0003530947],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.03195761,0.01091077,0.004896636,0.8072254,0.001307555,0.0006658374,0.003734614,0.0004175328,0.1388841],"genre_scores_gemma":[0.6129563,0.01119011,0.008606329,0.3274572,0.002029971,0.0005331683,0.002016417,0.0005363291,0.03467414],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.9369338,"threshold_uncertainty_score":0.4575793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2272983899885209,"score_gpt":0.3637336439549743,"score_spread":0.1364352539664534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}