{"id":"W4398255875","doi":"10.1017/cjn.2024.152","title":"P.045 Trofinetide for the treatment of Rett syndrome: long-term safety and efficacy results from the open-label LILAC and LILAC-2 studies","year":2024,"lang":"en","type":"article","venue":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"lilac; Placebo; Lavender; Medicine; Vomiting; Internal medicine; Biology; Botany","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001745887,0.0003116677,0.000438409,0.0002544454,0.0001798677,0.000487792,0.0003823688,0.0005075577,0.007984073],"category_scores_gemma":[0.001982495,0.00009094165,0.0005987461,0.0003384374,0.0004286342,0.0005103046,0.0002053493,0.0007409037,0.00102866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002117436,"about_ca_system_score_gemma":0.0004196039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002287733,"about_ca_topic_score_gemma":0.0003836969,"domain_scores_codex":[0.9995199,0.0002106026,0.00006058105,0.00004653734,0.0001374882,0.00002484701],"domain_scores_gemma":[0.9979076,0.0007626668,0.0008497159,0.00008806578,0.0002280922,0.0001638324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.172919,0.005043481,0.02643664,0.005446479,0.002586943,0.0006258152,0.0003155279,0.0005243648,0.0360566,0.0006502374,0.01097368,0.7384212],"study_design_scores_gemma":[0.1269095,0.3833207,0.3521189,0.002861349,0.004212251,0.004894253,0.0005932603,0.003828902,0.03088013,0.001198226,0.08904813,0.0001343966],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.898182,0.0740983,0.002008079,0.00259099,0.0006708744,0.000792919,0.001923898,0.0002189425,0.01951406],"genre_scores_gemma":[0.9795455,0.01098444,0.002354699,0.001001785,0.0007855442,0.0003203332,0.00127172,0.000032422,0.003703662],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007984073,"threshold_uncertainty_score":0.02670938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05632749606932459,"score_gpt":0.3109770653664936,"score_spread":0.254649569297169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}