{"id":"W4398255890","doi":"10.1017/cjn.2024.79","title":"A.6 INDIGO: a global, randomized, double-blinded, Phase 3 study of vorasidenib versus placebo in patients with grade 2 glioma with an IDH1/2 mutation (mIDH1/2)","year":2024,"lang":"en","type":"article","venue":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Public Health","funders":"","keywords":"Medicine; Glioma; Placebo; Internal medicine; Gastroenterology; Randomized controlled trial; Chemoradiotherapy; Chemotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001199289,0.00155347,0.002011724,0.000700358,0.0003981833,0.001229687,0.000904664,0.001576978,0.006878779],"category_scores_gemma":[0.0008596285,0.0006332527,0.001477685,0.0004546508,0.001186804,0.000996003,0.000384577,0.002222461,0.001335783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006450265,"about_ca_system_score_gemma":0.001296073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007680064,"about_ca_topic_score_gemma":0.003004681,"domain_scores_codex":[0.9995918,0.0002277777,0.00001710023,0.00006433569,0.00002997825,0.00006893568],"domain_scores_gemma":[0.999652,0.00006826414,0.00008916833,0.00002303565,0.00002245846,0.0001451625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9615938,0.006915658,0.0006703003,0.0006456493,0.0006984746,0.00004934706,0.0000713185,0.0003579347,0.006886916,0.000171472,0.001232503,0.02070656],"study_design_scores_gemma":[0.9476307,0.04844758,0.001861109,0.00003166436,0.0003026166,0.00004387115,0.00002324338,0.0003554184,0.0004716508,0.0001402297,0.0006779606,0.00001397792],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814327,0.006528847,0.0007579147,0.001097238,0.0004110118,0.003752617,0.001735435,0.0003386551,0.00394557],"genre_scores_gemma":[0.9825363,0.003027279,0.001799817,0.001823909,0.0002421264,0.004615509,0.001404672,0.00004015971,0.004510195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006878779,"threshold_uncertainty_score":0.02301186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0443606111115101,"score_gpt":0.326975909124167,"score_spread":0.2826152980126568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}