{"id":"W4398749064","doi":"10.1093/ibd/izae081","title":"Challenges in IBD Research 2024: Preclinical Human IBD Mechanisms","year":2024,"lang":"en","type":"review","venue":"Inflammatory Bowel Diseases","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Janssen Biotech; National Institute of Diabetes and Digestive and Kidney Diseases; Pfizer; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Incyte; Merck","keywords":"Medicine; Inflammatory bowel disease; Translational research; Multidisciplinary approach; Prioritization; Inflammatory Bowel Diseases; Disease; Bioinformatics; Management science; Pathology; Biology; Political science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002015043,0.001272765,0.001607374,0.0009644768,0.0002735483,0.0002489501,0.001683663,0.001521362,0.0002719713],"category_scores_gemma":[0.0007913155,0.001164646,0.001552183,0.0003789488,0.0005648343,0.00002621428,0.001533364,0.001642514,0.00165241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002743161,"about_ca_system_score_gemma":0.001990959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006016748,"about_ca_topic_score_gemma":0.0002819558,"domain_scores_codex":[0.9911107,0.001981941,0.001884597,0.002506923,0.001098886,0.001416956],"domain_scores_gemma":[0.995877,0.0001875874,0.0003670246,0.002467187,0.000264682,0.0008365171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008042342,0.002243123,0.0007694753,0.2192582,0.003041646,0.02905487,0.0003165554,0.00002404248,0.0001653119,0.03101361,0.08953187,0.6237771],"study_design_scores_gemma":[0.000548849,0.0001743743,0.00226245,0.01222572,0.001054044,0.00004391817,0.000123334,0.000004957051,0.000006822173,0.003596803,0.9785316,0.001427113],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008381136,0.9904125,0.000002302405,0.00004523035,0.001127482,0.002222743,0.0005277749,0.0001641887,0.004659675],"genre_scores_gemma":[0.0007682832,0.990804,0.00003114322,0.00003739344,0.001859994,0.002036274,0.0008759098,0.0004047089,0.003182293],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8889998,"threshold_uncertainty_score":0.9997749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1229557494438057,"score_gpt":0.4101900501147616,"score_spread":0.2872343006709559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}