{"id":"W4398764055","doi":"10.1038/s41577-024-01050-4","title":"Breast cancer-associated fibroblasts maintain self-renewing immunosuppressive macrophages","year":2024,"lang":"en","type":"review","venue":"Nature reviews. Immunology","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Disability Prevention and Rehabilitation; University of Toronto","funders":"","keywords":"Cancer-Associated Fibroblasts; Cancer; Breast cancer; Cancer research; Immunology; Self Tolerance; Medicine; Immune system; Cancer cell; Internal medicine; T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"category_scores_codex":[0.001393366,0.002650298,0.008432564,0.001001218,0.0005448911,0.0001414985,0.002974882,0.00939072,0.002827734],"category_scores_gemma":[0.0003479951,0.001999907,0.003110331,0.001802602,0.0007423552,0.000240346,0.001678214,0.01233297,0.008775315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002447639,"about_ca_system_score_gemma":0.001440993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001965794,"about_ca_topic_score_gemma":0.00004310439,"domain_scores_codex":[0.9881846,0.003883756,0.003098351,0.00233247,0.0001769186,0.002323865],"domain_scores_gemma":[0.9940146,0.0008089459,0.002418661,0.002339629,0.0003450839,0.00007304787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005582994,0.0002401131,0.000001461848,0.02267373,0.01077376,0.0001712265,0.0001794194,3.513702e-7,0.0005945966,0.0005792919,0.0665863,0.8981439],"study_design_scores_gemma":[0.0007754058,0.0001298901,0.000007292589,0.06333949,0.006796617,0.003349851,0.00002634015,2.488111e-7,0.0001740138,0.00009734155,0.9236869,0.001616672],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000009637493,0.9754348,0.000003675507,0.0001806432,0.01797149,0.003165268,0.001709881,0.0008384094,0.000686192],"genre_scores_gemma":[0.00004989747,0.9860864,0.00009795613,0.0002312022,0.0004561899,0.001798425,0.002396519,0.0005005451,0.008382835],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8965272,"threshold_uncertainty_score":0.9986231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01332117783325867,"score_gpt":0.3255312724870092,"score_spread":0.3122100946537505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}