{"id":"W4398775452","doi":"10.1016/j.semarthrit.2024.152479","title":"Advancing autoimmune Rheumatic disease treatment: CAR-T Cell Therapies - Evidence, Safety, and future directions","year":2024,"lang":"en","type":"review","venue":"Seminars in Arthritis and Rheumatism","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kingston Health Sciences Centre; Queen's University","funders":"","keywords":"Medicine; Rheumatic disease; Autoimmune disease; Disease; Dermatology; Immunology; Intensive care medicine; Rheumatoid arthritis; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006375648,0.0006952242,0.001673516,0.001957572,0.0003315323,0.002518017,0.0008676412,0.002510252,0.005743332],"category_scores_gemma":[0.008110725,0.0002882479,0.001243685,0.001816051,0.0009207653,0.003291488,0.000942423,0.002664121,0.00124183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0011689,"about_ca_system_score_gemma":0.003199501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008256791,"about_ca_topic_score_gemma":0.001894512,"domain_scores_codex":[0.9975632,0.001033919,0.0004263433,0.0002096586,0.0006334239,0.0001333515],"domain_scores_gemma":[0.9889618,0.00786436,0.001185265,0.0001764759,0.00154675,0.0002653493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003279804,0.0001016939,0.0005878716,0.0665763,0.000317023,0.000172289,0.000101778,0.000288634,0.0009711299,0.005893356,0.02431924,0.9003427],"study_design_scores_gemma":[0.0002505731,0.001103507,0.002191861,0.1563147,0.002028755,0.001725081,0.0005647077,0.000490025,0.001004769,0.01401409,0.8202538,0.00005819976],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001198731,0.9964781,0.000107045,0.002492797,0.0002655739,0.000008881164,0.00001626457,0.000004003871,0.0005073447],"genre_scores_gemma":[0.002559064,0.9936634,0.0004313203,0.002199841,0.0009061235,0.00002031252,0.00003582138,0.000002308266,0.0001818382],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006375648,"threshold_uncertainty_score":0.03371811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01972151068551317,"score_gpt":0.3233872758252732,"score_spread":0.30366576513976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}