{"id":"W4398775452","doi":"10.1016/j.semarthrit.2024.152479","title":"Advancing autoimmune Rheumatic disease treatment: CAR-T Cell Therapies - Evidence, Safety, and future directions","year":2024,"lang":"en","type":"review","venue":"Seminars in Arthritis and Rheumatism","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kingston Health Sciences Centre; Queen's University","funders":"","keywords":"Medicine; Rheumatic disease; Autoimmune disease; Disease; Dermatology; Immunology; Intensive care medicine; Rheumatoid arthritis; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000552538,0.0007213123,0.002374675,0.0006541319,0.0002645305,0.0001763559,0.0001247573,0.0003178994,0.0007965295],"category_scores_gemma":[0.00007415962,0.0005299645,0.0004063433,0.0006047328,0.0002685175,0.0001929212,0.0001554315,0.0007459992,0.00004072493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004181649,"about_ca_system_score_gemma":0.0004577902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002454888,"about_ca_topic_score_gemma":0.0001859292,"domain_scores_codex":[0.9969605,0.0002965408,0.0009712009,0.000803531,0.0003959695,0.0005722818],"domain_scores_gemma":[0.9982079,0.0005814979,0.00018508,0.0006101115,0.00004107288,0.0003743179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005014502,0.0001087067,0.00004439208,0.0174842,0.0002227293,0.0003466612,0.002101333,1.092136e-7,0.000005331988,0.00008291653,0.0003266777,0.9792268],"study_design_scores_gemma":[0.0006717553,0.0002718284,0.0002038395,0.3572032,0.000427146,0.0005536288,0.0002803408,0.00003068614,4.259653e-7,0.0001306578,0.6399044,0.0003221029],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005051132,0.9951965,0.000001799144,0.000576557,0.0006028172,0.001970429,0.0001411872,0.0001158825,0.0008897739],"genre_scores_gemma":[0.0001068116,0.9872957,0.0002620359,0.00001633807,0.0001696626,0.0003971621,0.0001242267,0.0001452689,0.01148281],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9789047,"threshold_uncertainty_score":0.9997152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01972151068551317,"score_gpt":0.3233872758252732,"score_spread":0.30366576513976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}