{"id":"W4398776853","doi":"10.21203/rs.3.rs-4420818/v1","title":"Dolutegravir Disrupts Mouse Blood-Brain Barrier by Inducing Endoplasmic Reticulum Stress ","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Endoplasmic reticulum; Blood–brain barrier; Dolutegravir; Unfolded protein response; Medicine; Neuroscience; Biology; Virology; Cell biology; Internal medicine; Central nervous system; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007630594,0.00032076,0.0003375697,0.0002577392,0.0001929276,0.0003468432,0.0001572109,0.0002055122,0.001389614],"category_scores_gemma":[0.00005749918,0.0001049581,0.0004060955,0.0003285896,0.0001427939,0.0001537257,0.000158518,0.0005378082,0.0005575941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002407216,"about_ca_system_score_gemma":0.0002278857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000519447,"about_ca_topic_score_gemma":0.0007611796,"domain_scores_codex":[0.9998448,0.00001019269,0.00001368911,0.00004914637,0.00004937963,0.00003273589],"domain_scores_gemma":[0.999952,0.000005451094,0.00001683102,0.000004740403,0.000009261515,0.00001178295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001831327,0.00001870284,0.0002487693,0.00009201589,0.000008244612,0.00004867665,0.00001153743,0.00005114958,0.9979433,0.00004055792,0.0001155228,0.001238467],"study_design_scores_gemma":[0.00002350563,0.00055503,0.01870308,0.00003414609,0.00005308459,0.0003591415,0.0000876769,0.001123015,0.9703341,0.000157892,0.008555281,0.00001414956],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9709565,0.005305387,0.006601354,0.0003112096,0.0001277371,0.0001024092,0.01308256,0.000449164,0.003063647],"genre_scores_gemma":[0.9511944,0.006219897,0.01001744,0.000513019,0.00004012608,0.0002351794,0.02103682,0.0001210591,0.01062216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001389614,"threshold_uncertainty_score":0.004648745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01781084693590047,"score_gpt":0.3435472816103803,"score_spread":0.3257364346744798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}