{"id":"W4398777972","doi":"10.1021/acs.molpharmaceut.4c00007","title":"Synergistic Nanomedicine Delivering Topoisomerase I Toxin (SN-38) and Inhibitors of Polynucleotide Kinase 3′-Phosphatase (PNKP) for Enhanced Treatment of Colorectal Cancer","year":2024,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Cancer Foundation; Ministry of Higher Education and Scientific Research; NanoMedicines Innovation Network","keywords":"Cytotoxicity; Chemistry; Stereochemistry; Topoisomerase; Enzyme; Micelle; Nuclear chemistry; Biochemistry; Organic chemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001420586,0.0003641745,0.0002417863,0.0001845618,0.00008095599,0.0001339999,0.000168831,0.0002788957,0.0005697195],"category_scores_gemma":[0.0001061511,0.0001348849,0.0002010239,0.0001080568,0.0001186958,0.000197841,0.0002108061,0.0002849852,0.0001827466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002489765,"about_ca_system_score_gemma":0.0001686659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002467198,"about_ca_topic_score_gemma":0.0006151724,"domain_scores_codex":[0.9999062,0.00001965817,0.000007225922,0.00002232179,0.00002908172,0.00001541824],"domain_scores_gemma":[0.9999669,0.000006886779,0.00001277357,0.000002116394,0.000004574434,0.000006803418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005215555,0.00001994096,0.00004990614,0.00006015749,0.000005694024,0.00002528353,0.000006016027,0.0001282202,0.9972995,0.00004551305,0.00002071046,0.002286861],"study_design_scores_gemma":[0.00002091037,0.000686915,0.0005106399,0.000005048553,0.00002555158,0.000193514,0.000007677084,0.001191237,0.994365,0.00002286646,0.002967039,0.000003672785],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9750298,0.0103345,0.01213658,0.0001717012,0.00006632253,0.0001085429,0.00009989212,0.0000974403,0.001955106],"genre_scores_gemma":[0.9844899,0.002679748,0.01099594,0.00005099124,0.00001548583,0.00007045284,0.00007330766,0.000009335643,0.001614887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005697195,"threshold_uncertainty_score":0.001905918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01529098888594098,"score_gpt":0.3160254444202626,"score_spread":0.3007344555343216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}