{"id":"W4398777972","doi":"10.1021/acs.molpharmaceut.4c00007","title":"Synergistic Nanomedicine Delivering Topoisomerase I Toxin (SN-38) and Inhibitors of Polynucleotide Kinase 3′-Phosphatase (PNKP) for Enhanced Treatment of Colorectal Cancer","year":2024,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Cancer Foundation; Ministry of Higher Education and Scientific Research; NanoMedicines Innovation Network","keywords":"Cytotoxicity; Chemistry; Stereochemistry; Topoisomerase; Enzyme; Micelle; Nuclear chemistry; Biochemistry; Organic chemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008935053,0.0002223867,0.0002699902,0.00007714977,0.00003905669,0.00001379444,0.0000861002,0.00009036569,0.00002207064],"category_scores_gemma":[0.00001431125,0.0002090592,0.0001377265,0.0001234855,0.0001123687,0.000004422557,0.00005136388,0.00004637655,4.119627e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005606962,"about_ca_system_score_gemma":0.0001258035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009782352,"about_ca_topic_score_gemma":0.00002647659,"domain_scores_codex":[0.9989434,0.00002442824,0.0003085082,0.0003474697,0.0001296436,0.0002465803],"domain_scores_gemma":[0.9995006,0.00002498461,0.00008933108,0.0001732464,0.00008852142,0.0001233099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003384368,0.0001139721,0.00001855709,0.0002702108,0.000331072,0.00002383187,0.0001726616,0.0002209807,0.9620616,0.0004083094,0.00003481188,0.03600557],"study_design_scores_gemma":[0.001514944,0.001055069,0.000009253575,0.00009553979,0.000311203,0.00000507473,0.00005452368,0.001841014,0.9763076,0.00005949381,0.01854794,0.0001983987],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.938273,0.05197123,0.008185018,0.0001065978,0.0004773317,0.0004836282,0.0004547497,0.00001336546,0.00003509868],"genre_scores_gemma":[0.9932097,0.005494695,0.0007166396,0.0001256253,0.0001170722,0.0001043068,0.0001154174,0.0000466408,0.00006992157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0549367,"threshold_uncertainty_score":0.8525186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01529098888594098,"score_gpt":0.3160254444202626,"score_spread":0.3007344555343216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}