{"id":"W4398781229","doi":"10.1002/mco2.560","title":"Therapeutic targeting of white adipose tissue metabolic dysfunction in obesity: mechanisms and opportunities","year":2024,"lang":"en","type":"review","venue":"MedComm","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"CAE (Canada)","funders":"Shanghai Hospital Development Center; National Natural Science Foundation of China; Innovative Research Team of High-level Local University in Shanghai","keywords":"Adipose tissue; White adipose tissue; Inflammation; Biology; Insulin resistance; Fibrosis; Adipose tissue macrophages; Adipogenesis; Medicine; Internal medicine; Endocrinology; Cancer research; Immunology; Obesity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007698007,0.0004886558,0.002667546,0.0006886553,0.00006146209,0.00002043451,0.0001335581,0.0003691441,0.0002041401],"category_scores_gemma":[0.00004976791,0.0003598955,0.0002456351,0.0003673303,0.00008437905,0.0000892338,0.000179532,0.0006545272,0.0000495514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003782928,"about_ca_system_score_gemma":0.0002501387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004703231,"about_ca_topic_score_gemma":0.00001407466,"domain_scores_codex":[0.9978495,0.0002500231,0.0008314032,0.0004236942,0.0003119684,0.000333411],"domain_scores_gemma":[0.9990163,0.000081094,0.000268968,0.0004056249,0.00006223491,0.000165806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000008951813,0.00007189623,0.000006146405,0.01904125,0.0004363693,0.0001584813,0.0006626624,5.184955e-8,0.00003600838,0.006823606,0.0003407446,0.9724138],"study_design_scores_gemma":[0.0003170786,0.0001056979,0.00002474085,0.009294352,0.008420581,0.0001947869,0.0001327582,0.000005893201,0.00006019705,0.0007578273,0.9804116,0.0002745198],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006305773,0.9967101,0.0001842244,0.0001931917,0.0006525061,0.0009373491,0.00003168103,0.00007531419,0.001152598],"genre_scores_gemma":[0.0003432051,0.990975,0.0005393221,0.0001762867,0.0002867065,0.00009518573,0.0001652511,0.000110193,0.007308889],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9800708,"threshold_uncertainty_score":0.9998853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07578256762543967,"score_gpt":0.3324088308896337,"score_spread":0.2566262632641941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}