{"id":"W4398781787","doi":"10.1007/s10067-024-07014-2","title":"Interactions of cumulative load with biomarkers of cartilage turnover predict knee cartilage change over 2 years: data from the osteoarthritis initiative","year":2024,"lang":"en","type":"article","venue":"Clinical Rheumatology","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hamilton Health Sciences; McMaster University; University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Cartilage; Osteoarthritis; Cartilage oligomeric matrix protein; Medicine; Knee pain; Internal medicine; Body mass index; Tibia; Rheumatology; Pathology; Surgery; Anatomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000397052,0.0002055727,0.0007677256,0.00007802473,0.00003424514,0.0000142377,0.0002142403,0.0001899799,0.0006143803],"category_scores_gemma":[0.0006363144,0.0001377966,0.00018155,0.0002582372,0.0006512695,0.0002741739,0.0002328251,0.0003501636,0.00006409033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003907106,"about_ca_system_score_gemma":0.0002888255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002696521,"about_ca_topic_score_gemma":0.001520937,"domain_scores_codex":[0.9978471,0.0002371811,0.0008366279,0.0005262187,0.0003053561,0.0002474881],"domain_scores_gemma":[0.9961243,0.002499575,0.0002579248,0.0008585711,0.0001378918,0.0001217882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0157202,0.003138229,0.6415285,0.0008605327,0.005359632,0.0034301,0.02680663,0.00000165301,0.01217897,0.005282821,0.03621681,0.2494759],"study_design_scores_gemma":[0.1064941,0.07534058,0.4867795,0.04625785,0.01293661,0.002764078,0.01900515,0.003423359,0.04547436,0.006579827,0.1918702,0.003074511],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904403,0.004354076,0.00006046327,0.0005773828,0.001052905,0.0007660197,0.001602571,0.00006490478,0.001081369],"genre_scores_gemma":[0.9984488,0.0003123097,0.0002657695,0.0001898322,0.0001026418,0.0000547385,0.0005017523,0.00003515153,0.00008895431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2464014,"threshold_uncertainty_score":0.6727033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09514491946834851,"score_gpt":0.3704818200483195,"score_spread":0.275336900579971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}