{"id":"W4399021672","doi":"10.1002/1878-0261.13658","title":"Spliceosomic dysregulation in pancreatic cancer uncovers splicing factors <scp>PRPF8</scp> and <scp>RBMX</scp> as novel candidate actionable targets","year":2024,"lang":"en","type":"article","venue":"Molecular Oncology","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Hospital Foundation","funders":"European Social Fund; Agencia Estatal de Investigación; Instituto de Salud Carlos III; Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición; Ministero dell'Università e della Ricerca; Innovative Research Group Project of the National Natural Science Foundation of China; Università degli Studi di Verona; Associazione Italiana per la Ricerca sul Cancro; Junta de Andalucía; European Cooperation in Science and Technology; Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España; Fondazione Cassa di Risparmio di Verona Vicenza Belluno e Ancona; Fondazione Italiana per la ricerca sulle Malattie del Pancreas; Ministerio de Ciencia e Innovación; European Regional Development Fund; European Commission; Fundación Eugenio Rodríguez Pascual","keywords":"Pancreatic cancer; RNA splicing; Biology; Alternative splicing; Genetics; Computational biology; Cancer research; Cancer; Bioinformatics; Gene; Exon","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009579234,0.0002135367,0.0001713798,0.0001794162,0.0001024819,0.0001958785,0.0001088385,0.0001897438,0.0006037761],"category_scores_gemma":[0.00007013278,0.00008422414,0.0001514875,0.0001249733,0.0001555404,0.0001157307,0.0001053533,0.0002544663,0.0001598148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001483211,"about_ca_system_score_gemma":0.0001216028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001894773,"about_ca_topic_score_gemma":0.0002993742,"domain_scores_codex":[0.9999408,0.000009472209,0.000004717368,0.00001562597,0.00001889301,0.00001051673],"domain_scores_gemma":[0.999966,0.000005398551,0.00001463417,0.000003930171,0.000004188719,0.000005843291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006565117,0.000006940124,0.0007235638,0.00002551047,0.000005793516,0.00009277196,0.000007505078,0.00006416242,0.996567,0.00006454908,0.00002746443,0.002349007],"study_design_scores_gemma":[0.000008780287,0.000297918,0.02424648,0.000008961245,0.00003595354,0.001173172,0.00005752931,0.001489776,0.9690957,0.000187508,0.003393026,0.000005219242],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938357,0.002356401,0.002568037,0.0000867234,0.00001495108,0.00001173501,0.0002288242,0.00007386685,0.0008237677],"genre_scores_gemma":[0.9966459,0.001213619,0.001240526,0.00003126782,0.000004359995,0.000009965217,0.0002540952,0.000008848467,0.0005914715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006037761,"threshold_uncertainty_score":0.002019823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009968820175737074,"score_gpt":0.2807676250156134,"score_spread":0.2707988048398763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}