{"id":"W4399021672","doi":"10.1002/1878-0261.13658","title":"Spliceosomic dysregulation in pancreatic cancer uncovers splicing factors <scp>PRPF8</scp> and <scp>RBMX</scp> as novel candidate actionable targets","year":2024,"lang":"en","type":"article","venue":"Molecular Oncology","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Hospital Foundation","funders":"European Social Fund; Agencia Estatal de Investigación; Instituto de Salud Carlos III; Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición; Ministero dell'Università e della Ricerca; Innovative Research Group Project of the National Natural Science Foundation of China; Università degli Studi di Verona; Associazione Italiana per la Ricerca sul Cancro; Junta de Andalucía; European Cooperation in Science and Technology; Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España; Fondazione Cassa di Risparmio di Verona Vicenza Belluno e Ancona; Fondazione Italiana per la ricerca sulle Malattie del Pancreas; Ministerio de Ciencia e Innovación; European Regional Development Fund; European Commission; Fundación Eugenio Rodríguez Pascual","keywords":"Pancreatic cancer; RNA splicing; Biology; Alternative splicing; Genetics; Computational biology; Cancer research; Cancer; Bioinformatics; Gene; Exon","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002097181,0.0003030838,0.0003197615,0.0002041393,0.0001321755,0.00008135619,0.0001720306,0.0003783664,0.0000210956],"category_scores_gemma":[0.0001656056,0.0003031609,0.0001030136,0.0003174302,0.0001222213,0.00002492015,0.0001091771,0.0002407469,0.00001886374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003327144,"about_ca_system_score_gemma":0.0005388533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00212942,"about_ca_topic_score_gemma":0.0008937355,"domain_scores_codex":[0.9981562,0.00008773469,0.0003427294,0.0007439735,0.0001777976,0.0004915353],"domain_scores_gemma":[0.9991948,0.0001076014,0.0001230305,0.0003497208,0.00007717607,0.0001476925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001128513,0.00007509386,0.007517839,0.00007687703,0.0001727749,0.0000332791,0.0003645188,0.00360111,0.9834434,0.000900102,0.001765146,0.002038611],"study_design_scores_gemma":[0.0017142,0.0005195838,0.04192119,0.0001271045,0.0002311704,0.00009393779,0.001201974,0.003463716,0.5552229,0.0007711455,0.3944995,0.000233534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842865,0.00757488,0.004297232,0.0002156837,0.0004687483,0.0004077978,0.00005570535,0.00003860705,0.00265488],"genre_scores_gemma":[0.9941835,0.001699251,0.0003701322,0.0004346352,0.000161673,0.0001974469,0.0002700852,0.00006306303,0.002620204],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4282205,"threshold_uncertainty_score":0.9999421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009968820175737074,"score_gpt":0.2807676250156134,"score_spread":0.2707988048398763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}