{"id":"W4399032715","doi":"10.1111/bjh.19569","title":"Outcomes of patients with secondary central nervous system lymphoma treated with chimeric antigen receptor T‐cell therapy: A <scp>CIBMTR</scp> analysis","year":2024,"lang":"en","type":"letter","venue":"British Journal of Haematology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cancer Moonshot; Moonshot Research and Development Program; National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; Office of Naval Research; Legend Biotech; Alexion Pharmaceuticals; bluebird bio; Pharmacyclics; Takeda Oncology; AstraZeneca; Genentech; Adaptive Biotechnologies; Health Resources and Services Administration; National Institutes of Health; MorphoSys; Seagen; Pediatric Blood and Marrow Transplant Consortium; Pediatric Transplantation and Cellular Therapy Consortium; CareDx; BeiGene; Juno Therapeutics; Swedish Orphan Biovitrum; Astellas Pharma; GlaxoSmithKline; Kiadis Pharma; Jazz Pharmaceuticals; Medical College of Wisconsin; Gateway for Cancer Research; Celgene; Omeros Corporation; Vertex Pharmaceuticals; Atara Biotherapeutics; Actinium Pharmaceuticals; National Cancer Institute; Gilead Sciences; CSL Behring; Bristol-Myers Squibb; Eli Lilly and Company; National Marrow Donor Program; Mallinckrodt Pharmaceuticals; Astellas Pharma US; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; Incyte; Pfizer; Amgen; Sanofi; HistoGenetics","keywords":"Chimeric antigen receptor; Medicine; Central nervous system; Lymphoma; Antigen; Receptor; Immunology; Oncology; Immunotherapy; Cancer research; Internal medicine; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000736036,0.0001988808,0.0005077033,0.0006505058,0.0002850009,0.0004207344,0.0003165914,0.0004450489,0.005701283],"category_scores_gemma":[0.002170944,0.0001241804,0.0008531546,0.001171799,0.0001612758,0.0004620212,0.0003682855,0.0006165666,0.0005801462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001020258,"about_ca_system_score_gemma":0.0004774293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004031113,"about_ca_topic_score_gemma":0.004815021,"domain_scores_codex":[0.9993047,0.0002029762,0.00007815458,0.0001050561,0.0001603648,0.0001488437],"domain_scores_gemma":[0.9983859,0.0004793634,0.0005311937,0.00009897285,0.0002232052,0.0002814652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0119152,0.0002093531,0.930172,0.0002821142,0.00117853,0.002010455,0.0001827566,0.001525142,0.0007804426,0.0003922796,0.02165113,0.02970069],"study_design_scores_gemma":[0.0008857578,0.001569205,0.9873954,0.00009386562,0.000611274,0.002300614,0.0002766146,0.001318974,0.0002184324,0.0005655539,0.00472983,0.00003452294],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9759405,0.00135909,0.0003600018,0.001298865,0.0001275597,0.0001048798,0.01454918,0.00001958212,0.00624026],"genre_scores_gemma":[0.9887143,0.0003859063,0.0001153607,0.0004353214,0.0001290068,0.0001260563,0.008573802,0.000009569734,0.00151069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005701283,"threshold_uncertainty_score":0.01907265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008835141096105326,"score_gpt":0.2326578795333325,"score_spread":0.2238227384372272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}