{"id":"W4399039541","doi":"10.1021/acs.chemrev.4c00142","title":"Mechanisms and Delivery of tRNA Therapeutics","year":2024,"lang":"en","type":"review","venue":"Chemical Reviews","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Chemistry; Transfer RNA; Computational biology; Biochemistry; RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005635915,0.001029518,0.001120764,0.001455042,0.0003189319,0.001208405,0.00107734,0.001531024,0.002813108],"category_scores_gemma":[0.0004519064,0.0004577381,0.0005822945,0.0009848333,0.0007218083,0.001573369,0.0007806226,0.002404286,0.002775848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001225911,"about_ca_system_score_gemma":0.0007975225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000689081,"about_ca_topic_score_gemma":0.000802724,"domain_scores_codex":[0.9997002,0.00006183473,0.00002725381,0.00005057823,0.0001193742,0.0000407289],"domain_scores_gemma":[0.9998871,0.00004970741,0.00001995196,0.000005816023,0.00002743055,0.00001007781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000116276,0.0001227178,0.0001262265,0.02371983,0.000111297,0.0006531539,0.0001643916,0.001627306,0.03803196,0.0656613,0.0401132,0.8295523],"study_design_scores_gemma":[0.00001198554,0.0000781837,0.0001431979,0.0009313348,0.00002586783,0.0008563439,0.00002078606,0.0001580232,0.004402317,0.003649096,0.9897071,0.00001579132],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003657402,0.9929932,0.001313673,0.0004530966,0.000451874,0.00001832485,0.00003515063,0.0000290958,0.004339818],"genre_scores_gemma":[0.002211293,0.9938222,0.0008080876,0.0003308755,0.0001389393,0.00003758126,0.00004653315,0.00000546041,0.002598977],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002813108,"threshold_uncertainty_score":0.009410739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07588731189545345,"score_gpt":0.3501860802263804,"score_spread":0.2742987683309269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}