{"id":"W4399039541","doi":"10.1021/acs.chemrev.4c00142","title":"Mechanisms and Delivery of tRNA Therapeutics","year":2024,"lang":"en","type":"review","venue":"Chemical Reviews","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Chemistry; Transfer RNA; Computational biology; Biochemistry; RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000186076,0.0003505038,0.001202078,0.00004207166,0.00001135723,0.00001733057,0.0002847769,0.0004065952,0.00001751504],"category_scores_gemma":[0.00003574574,0.0002338197,0.0006095074,0.00009448334,0.00007557352,0.000001551383,0.0002302625,0.0002105497,0.00008406134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000114599,"about_ca_system_score_gemma":0.00008829679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001300794,"about_ca_topic_score_gemma":4.201352e-7,"domain_scores_codex":[0.9986289,0.00005428283,0.000619114,0.0004458456,0.00008331947,0.0001685219],"domain_scores_gemma":[0.9992561,0.00001568105,0.0002073807,0.0004169038,0.00003703047,0.00006693342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00000337707,0.00001600402,7.061937e-8,0.01293536,0.0001492548,0.00000182725,0.000005245653,2.448961e-9,0.04053542,0.00004593654,0.003409065,0.9428985],"study_design_scores_gemma":[0.00003684278,0.00007069178,2.304271e-8,0.00670535,0.001039274,0.00003091145,0.000002175158,6.379958e-7,0.007320938,0.0001276796,0.9844371,0.0002283574],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001263883,0.9989198,0.00007408844,0.00000674023,0.0001355216,0.0003686965,0.00003711244,0.000006128279,0.0003255137],"genre_scores_gemma":[0.0000316925,0.9985482,0.0003977439,0.0001222381,0.0001278148,0.00006164597,0.0001632939,0.00004002933,0.0005073161],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9810281,"threshold_uncertainty_score":0.9534889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07588731189545345,"score_gpt":0.3501860802263804,"score_spread":0.2742987683309269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}