{"id":"W4399040074","doi":"10.1016/j.isci.2024.110122","title":"Human gut Actinobacteria boost drug absorption by secreting P-glycoprotein ATPase inhibitors","year":2024,"lang":"en","type":"article","venue":"iScience","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Complementary and Integrative Health; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Natural Sciences and Engineering Research Council of Canada; Burroughs Wellcome Fund; University of California, San Francisco; National Cancer Institute; National Institutes of Health; University of Washington; Damon Runyon Cancer Research Foundation","keywords":"Actinobacteria; ATPase; Chemistry; Biochemistry; Drug; Microbiology; Glycoprotein; Pharmacology; Biology; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000181627,0.0002740909,0.000448166,0.0002253622,0.0001657463,0.0004904346,0.00007978355,0.0003417367,0.003123972],"category_scores_gemma":[0.0004634645,0.0001585435,0.00025744,0.0002117759,0.0001876637,0.0001859674,0.000287957,0.0005214175,0.0006467427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002165059,"about_ca_system_score_gemma":0.0002898061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005666283,"about_ca_topic_score_gemma":0.0009725814,"domain_scores_codex":[0.9998,0.0000452424,0.000007792997,0.00004440979,0.00005168263,0.00005085919],"domain_scores_gemma":[0.9998286,0.00003794037,0.00004424382,0.0000133505,0.00003584697,0.0000400412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007919095,0.00009653654,0.005398193,0.0001619965,0.00003344206,0.0001488342,0.00004615162,0.0000752516,0.9776602,0.00009401795,0.0005501853,0.01494323],"study_design_scores_gemma":[0.0001823258,0.003612151,0.1713552,0.0001422998,0.0001860082,0.001604862,0.000840992,0.002155549,0.7863235,0.0007440108,0.0328244,0.00002878742],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803144,0.009387201,0.003472029,0.0009469774,0.0001332194,0.00007012119,0.00116888,0.0001528469,0.004354354],"genre_scores_gemma":[0.9879381,0.003896373,0.00282897,0.000464237,0.0000473323,0.00004565267,0.0009133556,0.00003670304,0.003829353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003123972,"threshold_uncertainty_score":0.01045072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0093872042037689,"score_gpt":0.2627645535374392,"score_spread":0.2533773493336703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}