{"id":"W4399042407","doi":"10.1038/s41420-024-02028-w","title":"PKA inhibition kills l-asparaginase-resistant leukemic cells from relapsed acute lymphoblastic leukemia patients","year":2024,"lang":"en","type":"article","venue":"Cell Death Discovery","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Gene knockdown; Apoptosis; Cancer research; Programmed cell death; Asparaginase; Downregulation and upregulation; Medicine; Lymphoblastic Leukemia; Biology; Pharmacology; Leukemia; Chemistry; Internal medicine; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001309054,0.0003304928,0.0006066047,0.000229351,0.0001494732,0.0004489363,0.0002325194,0.0002277528,0.002334432],"category_scores_gemma":[0.0001434553,0.0001538432,0.0003499387,0.0002486899,0.0001480052,0.0001281605,0.0002300869,0.0008927666,0.0007560643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002843441,"about_ca_system_score_gemma":0.0002511216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006179034,"about_ca_topic_score_gemma":0.0009398055,"domain_scores_codex":[0.9998789,0.00001994219,0.00001412598,0.00002049673,0.00003277749,0.00003370228],"domain_scores_gemma":[0.9999504,0.000006849071,0.000009019055,0.00001084734,0.000007991614,0.00001489965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001364342,0.0003597133,0.001695012,0.0001753432,0.00007270876,0.0002656529,0.00007618069,0.0005019649,0.9812198,0.0001856009,0.001125561,0.01295808],"study_design_scores_gemma":[0.0006309434,0.005162796,0.02638922,0.00002891843,0.0001534677,0.002043619,0.0002685586,0.00379705,0.9455298,0.0002173477,0.01575542,0.00002272064],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991998,0.003134581,0.001059356,0.0002735219,0.00007220063,0.00009196239,0.001498222,0.0001499825,0.001722049],"genre_scores_gemma":[0.9932852,0.001682164,0.0008670822,0.0001421184,0.00001514787,0.00007489254,0.001867396,0.00001856957,0.002047376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002334432,"threshold_uncertainty_score":0.00780952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009260088048401694,"score_gpt":0.2430950905025158,"score_spread":0.2338350024541141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}