{"id":"W4399042750","doi":"10.3390/pharmaceutics16060719","title":"Current Progress in Magnetic Resonance-Guided Focused Ultrasound to Facilitate Drug Delivery across the Blood-Brain Barrier","year":2024,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Focused ultrasound; Drug delivery; Clinical trial; Blood–brain barrier; Magnetic resonance imaging; Drug delivery to the brain; Drug; Ultrasound; Disease; Targeted drug delivery; Pharmacology; Central nervous system; Pathology; Internal medicine; Radiology; Nanotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003408482,0.0002247266,0.0001517784,0.000071058,0.0001184149,0.0001882159,0.000334222,0.00004363259,0.0001206978],"category_scores_gemma":[0.00002653136,0.0001819899,0.00007492684,0.0005772596,0.00009871412,0.000103057,0.00004673743,0.0004312572,0.0002404557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007594683,"about_ca_system_score_gemma":0.00004021465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001349343,"about_ca_topic_score_gemma":0.00009666745,"domain_scores_codex":[0.9986055,0.00004686956,0.0003016331,0.0002872371,0.0002111695,0.0005475308],"domain_scores_gemma":[0.9990897,0.0004013302,0.00001019759,0.0003043125,0.0000359486,0.0001585639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002538962,0.0001963239,0.01369388,0.0006084678,0.0001144142,0.00004744569,0.03663485,0.003596658,0.04069665,0.0008401042,0.02915228,0.8743935],"study_design_scores_gemma":[0.0004241508,0.00001175908,0.002820884,0.00009093652,0.00005153427,0.00001703246,0.0001782666,0.01174375,0.004933179,0.0002953334,0.9791331,0.000300023],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9141122,0.08233023,0.0001588581,0.001109795,0.0005439441,0.0006753993,0.0002909322,0.0004221238,0.0003565745],"genre_scores_gemma":[0.996237,0.001895445,0.0002630289,0.0002981049,0.0001759186,0.0004252036,0.00001541355,0.00006131154,0.0006285244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9499809,"threshold_uncertainty_score":0.7421333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04735874845015349,"score_gpt":0.3218134645233993,"score_spread":0.2744547160732458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}