{"id":"W4399047520","doi":"10.1111/bcpt.14035","title":"Regulation of mitochondrial dysfunction by estrogens and estrogen receptors in Alzheimer's disease: A focused review","year":2024,"lang":"en","type":"review","venue":"Basic & Clinical Pharmacology & Toxicology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Brain and Behavior Research Foundation","keywords":"Disease; Neuroscience; Estrogen; Pathological; Hormone; Alzheimer's disease; Perspective (graphical); Estrogen receptor; Bioinformatics; Receptor; Psychology; Medicine; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003668684,0.0006650815,0.0009695243,0.001756187,0.000270968,0.0007988917,0.0006091932,0.0008635672,0.003454528],"category_scores_gemma":[0.0005030113,0.0002185994,0.0003768843,0.001737881,0.0002619934,0.0009675196,0.0005257344,0.001093454,0.001562959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000510509,"about_ca_system_score_gemma":0.001079509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008611656,"about_ca_topic_score_gemma":0.001663718,"domain_scores_codex":[0.9998927,0.00001885373,0.00001838785,0.00001966619,0.00003859604,0.00001183698],"domain_scores_gemma":[0.9997846,0.00009509852,0.00003112419,0.000005528576,0.00006406131,0.0000194869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000098799,0.00007354894,0.0002089141,0.0297896,0.0001146776,0.0002286464,0.00009208631,0.0004100842,0.00322344,0.003822467,0.04292559,0.9190122],"study_design_scores_gemma":[0.00001439626,0.0001194868,0.0009129284,0.004610965,0.000132776,0.001078375,0.00007290181,0.00007634115,0.0005696448,0.001715096,0.9906793,0.00001782023],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001197769,0.9985807,0.00008935439,0.000234273,0.0002281296,0.00000418922,0.00002339523,0.000006147427,0.0007140583],"genre_scores_gemma":[0.0004722945,0.9987009,0.0001082913,0.0001358814,0.0001273793,0.000004397087,0.00002626674,9.785895e-7,0.0004235606],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003454528,"threshold_uncertainty_score":0.01155657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03746063374120926,"score_gpt":0.3901541899555329,"score_spread":0.3526935562143236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}