{"id":"W4399054684","doi":"10.1186/s13073-024-01322-7","title":"Metabolome-wide Mendelian randomization for age at menarche and age at natural menopause","year":2024,"lang":"en","type":"article","venue":"Genome Medicine","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal","funders":"Medical Research Council; Fonds de Recherche du Québec - Santé; Wellcome Trust","keywords":"Menarche; Mendelian randomization; Metabolome; Human genetics; Menopause; Medicine; Confounding; Mendelian inheritance; Bioinformatics; Physiology; Computational biology; Biology; Genetics; Internal medicine; Metabolomics; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001326388,0.0003508236,0.0009850127,0.0003876723,0.0001634335,0.00002294025,0.000112651,0.0001035316,0.0002997218],"category_scores_gemma":[0.00104363,0.0002375342,0.0001103274,0.0002945402,0.0003419909,0.0001102788,0.0001457836,0.0002406497,0.00005344129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003790381,"about_ca_system_score_gemma":0.00005463512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002912378,"about_ca_topic_score_gemma":0.00004525632,"domain_scores_codex":[0.9976551,0.00009392384,0.0005206118,0.0008010807,0.0004589033,0.0004704117],"domain_scores_gemma":[0.9984726,0.0005564369,0.00009172036,0.0004909665,0.0001338821,0.0002544371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003695605,0.0000420076,0.0004140437,0.0006114442,0.0008884371,0.000710427,0.003844765,0.000006362882,0.9698436,0.0003376802,0.008312079,0.01129357],"study_design_scores_gemma":[0.03319864,0.00130472,0.0185397,0.0002933006,0.002593322,0.0006640204,0.0003457644,0.000803476,0.006578211,0.00108491,0.9340733,0.0005207006],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7699223,0.1698916,0.002477919,0.04911187,0.001478809,0.003903789,0.00005242748,0.0003798452,0.002781459],"genre_scores_gemma":[0.9465945,0.00185186,0.001468162,0.001220168,0.001508738,0.0002067864,0.0004865499,0.00009241639,0.0465708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9632654,"threshold_uncertainty_score":0.9686365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02179337571205887,"score_gpt":0.2823358520816311,"score_spread":0.2605424763695723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}