{"id":"W4399054684","doi":"10.1186/s13073-024-01322-7","title":"Metabolome-wide Mendelian randomization for age at menarche and age at natural menopause","year":2024,"lang":"en","type":"article","venue":"Genome Medicine","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal","funders":"Medical Research Council; Fonds de Recherche du Québec - Santé; Wellcome Trust","keywords":"Menarche; Mendelian randomization; Metabolome; Human genetics; Menopause; Medicine; Confounding; Mendelian inheritance; Bioinformatics; Physiology; Computational biology; Biology; Genetics; Internal medicine; Metabolomics; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02990131,0.001058865,0.00216822,0.001540454,0.000880647,0.001492062,0.001625635,0.001484955,0.006254351],"category_scores_gemma":[0.04463419,0.0005375145,0.00477789,0.00210948,0.001302524,0.0007947626,0.001081135,0.001358385,0.0004130077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005797352,"about_ca_system_score_gemma":0.001160857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002993869,"about_ca_topic_score_gemma":0.001628205,"domain_scores_codex":[0.9714906,0.01827305,0.001186278,0.006550863,0.001666012,0.0008332289],"domain_scores_gemma":[0.9791803,0.01374242,0.001994832,0.004253691,0.0005613536,0.0002674047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04542498,0.0005943722,0.6742386,0.002777722,0.0691641,0.00402882,0.00135964,0.01788933,0.02386293,0.03242052,0.01315324,0.1150858],"study_design_scores_gemma":[0.009957924,0.008196561,0.6425936,0.0006759877,0.05054715,0.006488856,0.0005848774,0.1729976,0.01135016,0.06184407,0.03437312,0.0003900778],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6350214,0.00507833,0.3435275,0.001361344,0.0006645918,0.002208945,0.007406941,0.00190594,0.002825008],"genre_scores_gemma":[0.9464049,0.0004262615,0.04818804,0.0004257768,0.00007767189,0.001860915,0.001790677,0.0001667439,0.0006590218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02990131,"threshold_uncertainty_score":0.1581351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02179337571205887,"score_gpt":0.2823358520816311,"score_spread":0.2605424763695723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}