{"id":"W4399056876","doi":"10.1016/j.nbd.2024.106542","title":"Evidence of mutant huntingtin and tau-related pathology within neuronal grafts in Huntington’s disease cases","year":2024,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; Université Laval","funders":"National Institute on Aging; Alzheimer’s Disease Research Center, University of Washington; Fonds de Recherche du Québec - Santé; Nancy and Buster Alvord Endowment; Canadian Institutes of Health Research; Bio-oriented Technology Research Advancement Institution; National Institutes of Health","keywords":"Neuropil; Pathology; Huntingtin; Immunofluorescence; Tauopathy; Colocalization; Transplantation; Immunohistochemistry; Biology; Extracellular matrix; Extracellular; Huntington's disease; Molecular biology; Antibody; Cell biology; Neuroscience; Medicine; Neurodegeneration; Immunology; Central nervous system; Disease; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000287157,0.0002824773,0.0002634693,0.0009572551,0.0004175903,0.0003922523,0.0003092545,0.0004962845,0.001075308],"category_scores_gemma":[0.0004582537,0.0002498464,0.0002391874,0.0003805439,0.0005719376,0.0002497073,0.0005144209,0.0002633829,0.0002302256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002225252,"about_ca_system_score_gemma":0.0001581962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001338069,"about_ca_topic_score_gemma":0.002239238,"domain_scores_codex":[0.9998221,0.00001806714,0.00002796468,0.00003528492,0.00006368535,0.00003293461],"domain_scores_gemma":[0.9997123,0.00005219399,0.00006863487,0.00004269683,0.00004044996,0.0000838057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001476887,0.000207472,0.3736178,0.0001696524,0.0002149764,0.09090434,0.002348495,0.00030562,0.5213725,0.0003140202,0.0001428238,0.008925484],"study_design_scores_gemma":[0.00004962199,0.0009825112,0.7433745,0.0000225052,0.0001550794,0.2035119,0.001333459,0.0008520281,0.04850196,0.000237022,0.000949102,0.00003035096],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992657,0.0001447376,0.0001141708,0.000004472021,0.000002894409,0.000005797096,0.00001767122,0.000006093745,0.0004385464],"genre_scores_gemma":[0.9996184,0.0001124543,0.0001010174,0.000003912894,0.000002552213,0.000003103471,0.000041962,0.000001940992,0.0001146437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001338069,"threshold_uncertainty_score":0.0035972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03291392191612492,"score_gpt":0.2832902815383733,"score_spread":0.2503763596222484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}