{"id":"W4399070795","doi":"10.1186/s13058-024-01842-5","title":"Elevated expression of wildtype RhoC promotes ErbB2- and Pik3ca-induced mammary tumor formation","year":2024,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; McGill University; Hospital for Sick Children; University of Toronto","funders":"Cure Brain Cancer Foundation; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Hospital for Sick Children; University of Pennsylvania","keywords":"RhoC; Cancer research; Mammary tumor; Breast cancer; Biology; Cancer; Metastasis; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004987929,0.0000861661,0.000103673,0.0001219798,0.0000775488,0.00005605266,0.0001025299,0.00007659294,0.00003862149],"category_scores_gemma":[0.00003976145,0.0000709931,0.00003759936,0.0002177731,0.00005674238,0.00001932959,0.0001332171,0.0001298159,0.000003231757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002562604,"about_ca_system_score_gemma":0.0002046036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007469254,"about_ca_topic_score_gemma":0.00000985951,"domain_scores_codex":[0.9990017,0.0001158923,0.0001662173,0.0002430053,0.0002695291,0.0002036712],"domain_scores_gemma":[0.9994963,0.00001526633,0.00003299347,0.0001801371,0.0002040107,0.0000713179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002170558,0.00001935894,0.00007701784,0.0002501129,0.00001405594,0.000005931284,0.00004517932,0.000004159845,0.9829904,0.0002352525,0.0003370631,0.01580435],"study_design_scores_gemma":[0.0004142862,0.00008844044,0.001219647,0.0003546747,0.000004564796,0.00005667713,0.0000224287,0.001274128,0.9945116,0.0002752525,0.001692244,0.00008602699],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938233,0.00409635,0.0008455315,0.0005632095,0.00004672277,0.000400822,0.00003275526,0.00002172788,0.0001695234],"genre_scores_gemma":[0.9990847,0.0001986734,0.0002520373,0.00001847455,0.0001369079,0.00009757531,0.00003788205,0.0000154151,0.0001583942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01571832,"threshold_uncertainty_score":0.2895015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03233440374676855,"score_gpt":0.339612199007176,"score_spread":0.3072777952604074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}