{"id":"W4399071617","doi":"10.1016/j.jhep.2024.05.025","title":"CRISPR-Cas13b-mediated suppression of HBV replication and protein expression","year":2024,"lang":"en","type":"article","venue":"Journal of Hepatology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Infection and Immunity; National Health and Medical Research Council; Medical Research Council; Australian Centre for HIV and Hepatitis Virology Research","keywords":"HBsAg; Hepatitis B virus; cccDNA; Virology; CRISPR; Plasmid; Biology; Trans-activating crRNA; Viral replication; Hepatitis B virus PRE beta; RNA; Molecular biology; Virus; Cas9; DNA; Gene; Genetics; Hepatitis B virus DNA polymerase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002502018,0.0005432232,0.0005021967,0.0002423599,0.0002000268,0.000469067,0.0004075514,0.0005782215,0.002536789],"category_scores_gemma":[0.0002774111,0.0002395626,0.000428156,0.0001960278,0.0003563139,0.0001723062,0.0003553429,0.0008847952,0.001174645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004417209,"about_ca_system_score_gemma":0.0004513095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001177037,"about_ca_topic_score_gemma":0.001653575,"domain_scores_codex":[0.9997004,0.00003155239,0.00003579817,0.00007982849,0.0001135711,0.00003883757],"domain_scores_gemma":[0.9998049,0.00002722533,0.0000627038,0.00003014277,0.00004321006,0.00003181701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009008075,0.00002680569,0.0002729402,0.0001270741,0.00001727256,0.00006613612,0.00001523069,0.0002125204,0.9935522,0.0003134155,0.00031803,0.004988176],"study_design_scores_gemma":[0.00002634602,0.0001275375,0.001775022,0.00001404928,0.00002560239,0.0004127469,0.000009308555,0.003599357,0.9849208,0.00008563302,0.008992701,0.00001093175],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8190012,0.006177365,0.1497562,0.0007770354,0.0004212354,0.0004652248,0.003761112,0.003973446,0.01566728],"genre_scores_gemma":[0.9243544,0.001942728,0.05568979,0.0002675787,0.00003031848,0.0002821686,0.002513275,0.000265948,0.01465377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002536789,"threshold_uncertainty_score":0.00848645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02329383175437366,"score_gpt":0.3269857001663689,"score_spread":0.3036918684119952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}