{"id":"W4399072471","doi":"10.1182/blood.2023021426","title":"Adaptation to ex vivo culture reduces human hematopoietic stem cell activity independently of the cell cycle","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Cancer Research UK Cambridge Institute, University of Cambridge; NIHR Cambridge Biomedical Research Centre; Cambridge Institute for Medical Research, University of Cambridge; Blood Cancer UK; Wellcome Trust; Cambridge Trust; Gates Cambridge Trust; GlaxoSmithKline; Deutsche Forschungsgemeinschaft; National Institute for Health and Care Research; Cancer Research UK; Canada First Research Excellence Fund; Medical Research Council; Alborada Trust; University of Toronto","keywords":"Ex vivo; Biology; Haematopoiesis; Stem cell; Cell biology; Hematopoietic stem cell; Cell cycle; Cancer research; Immunology; In vivo; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001125059,0.0003133394,0.0001767148,0.0001078695,0.00009018325,0.0002785125,0.0001386792,0.000114461,0.0020207],"category_scores_gemma":[0.00009611432,0.00006626008,0.0001617602,0.00008022353,0.0001299603,0.0001123762,0.0001546827,0.0004418719,0.0003528895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001611984,"about_ca_system_score_gemma":0.0001524699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002495017,"about_ca_topic_score_gemma":0.0004623898,"domain_scores_codex":[0.9999108,0.00001805279,0.00000889464,0.00002223701,0.00002486227,0.00001499775],"domain_scores_gemma":[0.9999375,0.00001913586,0.00001596438,0.00001296458,0.000005963833,0.000008449368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009786114,0.00003393347,0.0001781403,0.00002650361,0.00000310207,0.00001314914,0.000007283843,0.00008602767,0.9971377,0.00004508308,0.00004816156,0.002323163],"study_design_scores_gemma":[0.000005201643,0.0001777266,0.002996207,0.000002753681,0.000008638609,0.00005292168,0.000006157125,0.0004253616,0.9948259,0.00001583954,0.001481567,0.000001567065],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842225,0.004681731,0.00851259,0.0001334801,0.00007169765,0.00005741,0.000517257,0.0001366536,0.00166682],"genre_scores_gemma":[0.9923004,0.001463177,0.002678443,0.00007557349,0.00002436425,0.00005641858,0.0008154067,0.00002962462,0.002556491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0020207,"threshold_uncertainty_score":0.006759882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01658238908918237,"score_gpt":0.2607879412197719,"score_spread":0.2442055521305896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}