{"id":"W4399072471","doi":"10.1182/blood.2023021426","title":"Adaptation to ex vivo culture reduces human hematopoietic stem cell activity independently of the cell cycle","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Cancer Research UK Cambridge Institute, University of Cambridge; NIHR Cambridge Biomedical Research Centre; Cambridge Institute for Medical Research, University of Cambridge; Blood Cancer UK; Wellcome Trust; Cambridge Trust; Gates Cambridge Trust; GlaxoSmithKline; Deutsche Forschungsgemeinschaft; National Institute for Health and Care Research; Cancer Research UK; Canada First Research Excellence Fund; Medical Research Council; Alborada Trust; University of Toronto","keywords":"Ex vivo; Biology; Haematopoiesis; Stem cell; Cell biology; Hematopoietic stem cell; Cell cycle; Cancer research; Immunology; In vivo; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001764166,0.0001657469,0.0002410835,0.00008499465,0.00007090364,0.00003348402,0.0001437247,0.0001297511,0.00007721641],"category_scores_gemma":[0.000004492038,0.0001178271,0.0001325707,0.0003355606,0.00003394634,0.00008208305,0.0000303387,0.0002183494,0.00007391234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003275886,"about_ca_system_score_gemma":0.0001025504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000457746,"about_ca_topic_score_gemma":0.00001779836,"domain_scores_codex":[0.9986669,0.00007185758,0.0002764993,0.0003101008,0.0004830098,0.0001916398],"domain_scores_gemma":[0.9993711,0.00005561981,0.00007889816,0.0003257445,0.00006343468,0.0001052167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002508539,0.0005020969,0.0003473758,0.001685959,0.00004706059,0.000036249,0.01621969,0.00003059616,0.9803419,0.0001032093,0.0002685887,0.0003922551],"study_design_scores_gemma":[0.0009364032,0.0001710577,0.001764961,0.0005903736,0.0004027259,0.00007094808,0.0018001,0.00007559288,0.9937463,0.00007436233,0.0002439929,0.0001232035],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849626,0.0004143259,0.0003374693,0.0002196618,0.000212743,0.0006548121,0.0000247349,0.00008760196,0.01308601],"genre_scores_gemma":[0.9955914,0.00002124473,0.000261603,0.00004784685,0.00008307878,0.00002523178,0.000006302922,0.00003274368,0.003930553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01441959,"threshold_uncertainty_score":0.4804851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01658238908918237,"score_gpt":0.2607879412197719,"score_spread":0.2442055521305896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}