{"id":"W4399088388","doi":"10.3390/genes15060705","title":"Inherited Retinal Diseases and Retinal Organoids as Preclinical Cell Models for Inherited Retinal Disease Research","year":2024,"lang":"en","type":"article","venue":"Genes","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; University of Toronto","keywords":"Retinal; Organoid; Context (archaeology); Neuroscience; Retina; Biology; Retinitis pigmentosa; Retinal degeneration","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001821525,0.0006706847,0.0008151439,0.001270817,0.000490422,0.001231969,0.0007200687,0.001276212,0.002567541],"category_scores_gemma":[0.000758498,0.0002894099,0.0008535954,0.0005821888,0.000810407,0.0008795031,0.0009192752,0.002398082,0.001328292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007991856,"about_ca_system_score_gemma":0.0006665244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008621559,"about_ca_topic_score_gemma":0.001404998,"domain_scores_codex":[0.9989362,0.0003643463,0.0001223338,0.0001692949,0.0003305365,0.00007730258],"domain_scores_gemma":[0.9993667,0.0002258071,0.00009490522,0.0001228342,0.0001089628,0.00008069579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005056316,0.0002849953,0.0008287895,0.001716411,0.00008756939,0.0009918479,0.0002860134,0.001151058,0.9481956,0.01554016,0.002684977,0.02772701],"study_design_scores_gemma":[0.0001541523,0.003103258,0.003057768,0.0008293936,0.0003622366,0.003735322,0.0003338972,0.00186607,0.7349392,0.004608066,0.2469183,0.00009227833],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3222956,0.3588328,0.2311767,0.005441132,0.003597055,0.002420752,0.01071582,0.001940963,0.06357913],"genre_scores_gemma":[0.6023892,0.2088868,0.1495231,0.001709664,0.0003497155,0.002753508,0.01065924,0.0003989843,0.02332978],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002567541,"threshold_uncertainty_score":0.009633243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04835332049783207,"score_gpt":0.3540769831323016,"score_spread":0.3057236626344695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}