{"id":"W4399088388","doi":"10.3390/genes15060705","title":"Inherited Retinal Diseases and Retinal Organoids as Preclinical Cell Models for Inherited Retinal Disease Research","year":2024,"lang":"en","type":"article","venue":"Genes","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University of Toronto","funders":"Canadian Institutes of Health Research; University of Toronto","keywords":"Retinal; Organoid; Context (archaeology); Neuroscience; Retina; Biology; Retinitis pigmentosa; Retinal degeneration","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005969221,0.0002768043,0.0002162757,0.0001274576,0.0002595057,0.0002021131,0.0002665916,0.0002080134,0.00007124808],"category_scores_gemma":[0.000388849,0.0002568614,0.0001481005,0.0002901551,0.0003432137,0.00001740936,0.0002948935,0.0002112458,0.00002678298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002037266,"about_ca_system_score_gemma":0.000449266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000200966,"about_ca_topic_score_gemma":0.000007314866,"domain_scores_codex":[0.9975879,0.0002052552,0.0003740196,0.0009007479,0.0003798762,0.0005521725],"domain_scores_gemma":[0.9988099,0.0001251912,0.00004673765,0.0003537503,0.0002759258,0.0003885333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.02123308,0.001280064,0.1298331,0.004773674,0.0004923805,0.0004455851,0.001088452,0.0002298627,0.6606355,0.004473414,0.1321269,0.04338789],"study_design_scores_gemma":[0.005613242,0.005354229,0.0986317,0.0009857364,0.0006077765,0.0001292898,0.001772138,0.01547121,0.06972449,0.04556309,0.7528073,0.003339792],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9689953,0.02612284,0.001130854,0.001281306,0.0002417047,0.0006307435,0.0001243737,0.00007228486,0.001400631],"genre_scores_gemma":[0.9874638,0.003670812,0.001741741,0.0002081577,0.0005923361,0.0002085337,0.0006814126,0.00007850507,0.005354723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6206803,"threshold_uncertainty_score":0.9999884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04835332049783207,"score_gpt":0.3540769831323016,"score_spread":0.3057236626344695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}