{"id":"W4399094831","doi":"10.1002/phar.2941","title":"Vancomycin: An analysis and evaluation of eight population pharmacokinetic models for clinical application in general adult population","year":2024,"lang":"en","type":"article","venue":"Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy","topic":"Antibiotics Pharmacokinetics and Efficacy","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Santé Montérégie; Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Réseau Québécois de Recherche sur les Médicaments","keywords":"Medicine; Dosing; NONMEM; Population; Vancomycin; Therapeutic drug monitoring; Bayesian probability; Intensive care medicine; Statistics; Pharmacokinetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005413512,0.0008889871,0.0008077071,0.0009780932,0.0002571327,0.0009292933,0.0007871828,0.0008143822,0.0006141734],"category_scores_gemma":[0.01063459,0.0002867406,0.001369841,0.0006374172,0.0002561515,0.0003617414,0.0005475348,0.0006892935,0.0001176831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001113675,"about_ca_system_score_gemma":0.001277651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01294467,"about_ca_topic_score_gemma":0.004511268,"domain_scores_codex":[0.9988317,0.0006556038,0.00006872427,0.0002115993,0.0001678958,0.00006449137],"domain_scores_gemma":[0.9917293,0.006707985,0.0005166793,0.0002536222,0.0006496018,0.0001428203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0006173214,0.0003398473,0.05802983,0.0001835648,0.0004879997,0.0002683956,0.00009906811,0.9086894,0.001065789,0.000772342,0.0008223031,0.02862417],"study_design_scores_gemma":[0.0000488311,0.0004224003,0.01138184,0.00002276571,0.000110353,0.00008528527,0.00003642164,0.9866179,0.0005775755,0.0003817209,0.0002965435,0.00001838514],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9679081,0.0006585133,0.0291124,0.0002737557,0.00002192299,0.0001700595,0.0008697732,0.0001974155,0.0007879425],"genre_scores_gemma":[0.9846786,0.000264441,0.01374605,0.00004717047,0.00001248266,0.0001131179,0.0009186698,0.00001476586,0.0002046892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01294467,"threshold_uncertainty_score":0.02862978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06251188778843791,"score_gpt":0.4587924961404524,"score_spread":0.3962806083520145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}