{"id":"W4399106479","doi":"10.1093/brain/awae168","title":"Failure of <i>C9orf72</i> sense repeat-targeting antisense oligonucleotides: lessons learned and the path forward","year":2024,"lang":"en","type":"letter","venue":"Brain","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Alzheimer’s Research UK; UK Dementia Research Institute; Academy of Medical Sciences; Medical Research Council Canada; LifeArc","keywords":"Sense (electronics); C9orf72; Oligonucleotide; Path (computing); Disappointment; Computer science; Medicine; Biology; Psychology; Disease; Internal medicine; Genetics; Engineering; Computer network","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009222525,0.0003592752,0.0007963923,0.0001977269,0.0001111164,0.00006836485,0.00015419,0.0004488537,0.00006341036],"category_scores_gemma":[0.000977512,0.0002348751,0.0004353755,0.0002826978,0.0006289537,0.00002311615,0.0002571451,0.001968229,0.00004829688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002032485,"about_ca_system_score_gemma":0.0002111341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009957662,"about_ca_topic_score_gemma":0.00001028458,"domain_scores_codex":[0.9971797,0.0004431854,0.0004637474,0.0006843186,0.0006983689,0.000530693],"domain_scores_gemma":[0.9981926,0.0006855321,0.0001483392,0.0007435487,0.0001259992,0.000103975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001332236,0.00001997409,0.00003518882,0.001611594,0.0003060501,0.002560689,0.0005517179,8.667106e-7,0.004023985,0.0001700089,0.9861997,0.00438697],"study_design_scores_gemma":[0.00229417,0.0001301944,0.00005076159,0.0006475431,0.0003933216,0.0005585456,0.000453195,0.000147644,0.0008965866,0.0006757493,0.993514,0.0002382763],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01817484,0.00541958,0.00005429667,0.9725582,0.0001440417,0.001104288,0.00008983044,0.00008014241,0.002374787],"genre_scores_gemma":[0.07194027,0.005706718,0.001321432,0.8835948,0.002798571,0.0001168525,0.0004802393,0.0004775257,0.03356365],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.08896346,"threshold_uncertainty_score":0.9577929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02402705301895439,"score_gpt":0.3078787008247608,"score_spread":0.2838516478058064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}