{"id":"W4399116899","doi":"10.1016/j.cbpa.2024.102472","title":"New reactions by pyridoxal phosphate-dependent enzymes","year":2024,"lang":"en","type":"review","venue":"Current Opinion in Chemical Biology","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia Hospital; University of British Columbia","funders":"","keywords":"Cofactor; Pyridoxal; Pyridoxal phosphate; Chemistry; Enzyme; Biochemistry; Pyridine; Pyridoxal 5-Phosphate; Stereochemistry; Combinatorial chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002082968,0.0004696233,0.001042482,0.0001625472,0.00003736246,0.00005926253,0.0004279134,0.000662345,0.001011901],"category_scores_gemma":[0.000100313,0.0003423278,0.0002926427,0.0003151768,0.0001060189,0.00007034212,0.0002253511,0.0008922969,0.001280659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002339546,"about_ca_system_score_gemma":0.0002544578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004563291,"about_ca_topic_score_gemma":0.000001247612,"domain_scores_codex":[0.9975229,0.0001234594,0.0008531392,0.0009074607,0.0001488779,0.0004441862],"domain_scores_gemma":[0.9990574,0.0001697691,0.0002392973,0.0003476619,0.00002526508,0.0001605973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000008492551,0.00004136744,0.000001789202,0.006184658,0.00002117521,5.160094e-7,0.0000147659,9.768452e-8,0.00358322,0.002812854,0.1862234,0.8011076],"study_design_scores_gemma":[0.000135687,0.00002916199,5.473705e-8,0.003710771,0.0001022015,0.00002752302,0.000002731444,0.000001005873,0.003542538,0.001358333,0.9907494,0.0003405641],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000004824575,0.9669579,0.0001779006,0.00005526886,0.03181374,0.0003227342,0.0002983054,0.0001452605,0.0002240187],"genre_scores_gemma":[0.00001646889,0.9957028,0.0001069876,0.000008822085,0.002376617,0.0001135363,0.001389514,0.00004001222,0.000245255],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.804526,"threshold_uncertainty_score":0.9999028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06813927624680041,"score_gpt":0.3888759593071802,"score_spread":0.3207366830603798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}