{"id":"W4399120991","doi":"10.1126/sciadv.adj1431","title":"<sup>13</sup> C metabolite tracing reveals glutamine and acetate as critical in vivo fuels for CD8 T cells","year":2024,"lang":"en","type":"article","venue":"Science Advances","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; Agios Pharmaceuticals","keywords":"Metabolite; In vivo; Glutamine; Tracing; Chemistry; Biochemistry; Biology; Biotechnology; Amino acid; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008450531,0.0001741098,0.0000837934,0.0001816509,0.0001476355,0.0002634997,0.0001773809,0.0003407304,0.001316343],"category_scores_gemma":[0.00008236251,0.0001158039,0.00007540602,0.0001788009,0.0002065794,0.000217131,0.0001409569,0.0003588681,0.0003873753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002836959,"about_ca_system_score_gemma":0.0001890403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006788131,"about_ca_topic_score_gemma":0.001538482,"domain_scores_codex":[0.9999561,0.000005234195,0.000001785561,0.00001187013,0.00001153652,0.00001336846],"domain_scores_gemma":[0.9999555,0.000008629279,0.00001116504,0.000005028563,0.000009483611,0.00001006051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002306184,0.000006563382,0.0006914123,0.0000172066,0.000002475626,0.00006890389,0.00001045744,0.0002146752,0.9949168,0.0003814996,0.0001862065,0.003273269],"study_design_scores_gemma":[0.00001106968,0.00008801388,0.004021691,0.000007066144,0.00001088902,0.0002111464,0.00003259011,0.002912082,0.9875748,0.000331701,0.004794546,0.000004523376],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9762799,0.002470154,0.01329708,0.0004983292,0.00007017074,0.00001374871,0.0007068748,0.00021651,0.006447249],"genre_scores_gemma":[0.9756025,0.001210037,0.01788526,0.0002215806,0.00001860166,0.00002300441,0.0006071947,0.0000801684,0.004351578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001316343,"threshold_uncertainty_score":0.004403591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009543710717964633,"score_gpt":0.3039527332526734,"score_spread":0.2944090225347087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}