{"id":"W4399121037","doi":"10.1038/s41467-024-48910-0","title":"Mucus production, host-microbiome interactions, hormone sensitivity, and innate immune responses modeled in human cervix chips","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Reproductive tract infections research","field":"Immunology and Microbiology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Hansjörg Wyss Institute for Biologically Inspired Engineering, Harvard University; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Harvard University; Bill and Melinda Gates Foundation","keywords":"Microbiome; Mucus; Innate immune system; Host (biology); Immune system; Cervical mucus; Hormone; Biology; Immunology; Cervix; Bioinformatics; Cancer; Endocrinology; Genetics; Ecology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003330749,0.0002483331,0.0002461019,0.000206699,0.0001768244,0.0004969109,0.0002468506,0.0003905808,0.001119928],"category_scores_gemma":[0.0003285714,0.0002188994,0.000333728,0.0002159869,0.0003186651,0.000208863,0.0004428168,0.0002978832,0.0002445807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002965808,"about_ca_system_score_gemma":0.0003360499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001611454,"about_ca_topic_score_gemma":0.002067317,"domain_scores_codex":[0.9997942,0.0000416548,0.00001003783,0.00004474597,0.00006819212,0.00004119826],"domain_scores_gemma":[0.9998264,0.00005422343,0.00003629352,0.00002833057,0.00002405985,0.00003062166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002003985,0.00003997335,0.002939999,0.0001115432,0.00001778855,0.0001409633,0.0001195546,0.001863656,0.9916739,0.0002226241,0.0001399933,0.002529751],"study_design_scores_gemma":[0.00002591132,0.001592193,0.03466384,0.00004500593,0.0000896444,0.0005145124,0.0006951792,0.01433251,0.9392164,0.0002780182,0.008496474,0.00005027789],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987488,0.001148996,0.008548894,0.00007900272,0.00003106705,0.00007577515,0.0008699218,0.00007116313,0.001687077],"genre_scores_gemma":[0.9900349,0.0007884048,0.006770694,0.00009508982,0.000005563501,0.0001366637,0.0007793577,0.00001952285,0.00136993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001611454,"threshold_uncertainty_score":0.003746569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02911936865987109,"score_gpt":0.3525974393701592,"score_spread":0.3234780707102882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}