{"id":"W4399123967","doi":"10.1007/s00384-024-04656-1","title":"Assessing circulating tumour DNA (ctDNA) as a prognostic biomarker in locally advanced rectal cancer: a systematic review and meta-analysis","year":2024,"lang":"en","type":"review","venue":"International Journal of Colorectal Disease","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Irish Research eLibrary","keywords":"Medicine; Internal medicine; Hazard ratio; Colorectal cancer; Oncology; Meta-analysis; Biomarker; Disease; Cancer; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005645702,0.0004262628,0.002708015,0.0004782995,0.00002975818,0.0002782204,0.0004635198,0.0001288401,0.00004109546],"category_scores_gemma":[0.001696871,0.0003141834,0.002183122,0.0004257397,0.00005678359,0.00002565966,0.0002168427,0.00027189,0.000004499911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002115577,"about_ca_system_score_gemma":0.001296401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001750366,"about_ca_topic_score_gemma":0.00005272738,"domain_scores_codex":[0.9971805,0.0002649664,0.001430429,0.0004451266,0.0004717717,0.0002072199],"domain_scores_gemma":[0.9976842,0.0001838132,0.001249126,0.0001820689,0.0004556553,0.0002450779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0002740093,0.0003885141,0.00008922617,0.6278628,0.3439627,0.003491055,0.00004819215,0.0002927143,0.0003129017,0.00008240639,0.0003891858,0.02280627],"study_design_scores_gemma":[0.0003462188,0.0001326182,0.0001156161,0.08366192,0.9089458,0.0005649209,0.00002214623,0.0001549927,0.000007714909,0.00009206711,0.005365605,0.0005903624],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001925092,0.9961625,0.00006208966,0.0002183238,0.0002930387,0.0009733549,0.00031263,0.000004997138,0.00004794706],"genre_scores_gemma":[0.04040802,0.9585856,0.00009381064,0.0002663504,0.0000980097,0.0003051045,0.0001442294,0.00004973519,0.00004916992],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5649831,"threshold_uncertainty_score":0.999931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04020851557730599,"score_gpt":0.3857512427064834,"score_spread":0.3455427271291774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}