{"id":"W4399124778","doi":"10.1101/2024.05.28.596157","title":"mRNA Vaccine-Induced SARS-CoV-2 Spike-Specific IFN-γ and IL-2 T-cell Responses are Predictive of Serological Neutralization and are Transiently Enhanced by Pre-Existing Cross-Reactive Immunity","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Toronto Public Health; Lunenfeld-Tanenbaum Research Institute; York University; University of Toronto","funders":"","keywords":"Virology; Serology; Neutralization; Immunity; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Spike Protein; Coronavirus disease 2019 (COVID-19); Biology; Immunology; Antibody; Immune system; Medicine; Virus; Infectious disease (medical specialty); Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000103639,0.0001812391,0.0001790826,0.00004585578,0.00004984109,0.0002018375,0.00009986116,0.0001405505,0.0006795151],"category_scores_gemma":[0.0002796199,0.0001032214,0.0002783089,0.00004162996,0.0001296897,0.0001558823,0.0001116673,0.0001967024,0.0001300897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003291204,"about_ca_system_score_gemma":0.0002402589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001385898,"about_ca_topic_score_gemma":0.00108989,"domain_scores_codex":[0.9999577,0.000006762887,0.00000181878,0.00001138919,0.000008616494,0.00001375563],"domain_scores_gemma":[0.9999421,0.00002282671,0.00001998229,0.000004802303,0.000006473517,0.000003872487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006494873,0.0001530397,0.02554949,0.000119222,0.00004565935,0.0001454357,0.00007271225,0.3475808,0.613793,0.001377964,0.0001262287,0.01038706],"study_design_scores_gemma":[0.00003653476,0.00105794,0.02681419,0.0000100345,0.00004817215,0.0001370313,0.00007429035,0.8145618,0.1552976,0.001206646,0.0007417025,0.00001404116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920358,0.00006429249,0.007242525,0.00002089881,0.00000293113,0.000007244143,0.00006547769,0.00002404271,0.0005367296],"genre_scores_gemma":[0.9985842,0.0000486774,0.0008701219,0.000004816673,5.950234e-7,0.000008109248,0.000070668,0.000003352929,0.0004095471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001385898,"threshold_uncertainty_score":0.002755702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04512756090556248,"score_gpt":0.320303125834114,"score_spread":0.2751755649285515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}