{"id":"W4399128816","doi":"10.1038/s41467-024-48196-2","title":"G protein-specific mechanisms in the serotonin 5-HT2A receptor regulate psychosis-related effects and memory deficits","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Agencia Estatal de Investigación; Instituto de Salud Carlos III; Canadian Institutes of Health Research; Ministerio de Ciencia e Innovación; European Regional Development Fund; Deutsche Forschungsgemeinschaft; Eusko Jaurlaritza; Bundesministerium für Bildung und Forschung; Xunta de Galicia; European Commission","keywords":"G protein-coupled receptor; Neuroscience; Psychosis; Schizophrenia (object-oriented programming); Receptor; Agonist; 5-HT receptor; Serotonin; Signal transduction; Endogenous agonist; Functional selectivity; Stimulation; Biology; Pharmacology; Cell biology; Psychology; Biochemistry; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005104239,0.0002352973,0.0001392153,0.00007740076,0.00007891753,0.0001684363,0.0001147497,0.0001984798,0.00082816],"category_scores_gemma":[0.00006428846,0.00007891009,0.0001718328,0.00005117062,0.0002252473,0.000115897,0.000134348,0.0002496866,0.00009780378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002786795,"about_ca_system_score_gemma":0.0002250813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002306247,"about_ca_topic_score_gemma":0.002580627,"domain_scores_codex":[0.9999803,0.00000421309,0.00000108727,0.000003979473,0.000004578179,0.000005895037],"domain_scores_gemma":[0.9999758,0.000003576678,0.00001151775,0.00000222499,0.000001660793,0.000005216507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002349838,0.00004045629,0.00315038,0.000051602,0.00003698417,0.0001866301,0.00001722681,0.005153004,0.9872844,0.0008238396,0.0001064261,0.002914045],"study_design_scores_gemma":[0.0001797278,0.001477183,0.1988606,0.00005479554,0.0002190758,0.001020069,0.0002527978,0.1097737,0.6805915,0.005059627,0.002461499,0.00004943429],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966452,0.0002254261,0.002384812,0.00006923859,0.000004838648,0.000006604937,0.00009526464,0.00004886186,0.0005198211],"genre_scores_gemma":[0.9991086,0.0001880725,0.0004735457,0.000019009,8.066141e-7,0.000003502252,0.00003110454,0.00000308008,0.0001721842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002306247,"threshold_uncertainty_score":0.004585624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009324325043515146,"score_gpt":0.2613900389727351,"score_spread":0.2520657139292199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}