{"id":"W4399139465","doi":"10.1111/acel.14194","title":"Maternal age is related to offspring <scp>DNA</scp> methylation: A meta‐analysis of results from the <scp>PACE</scp> consortium","year":2024,"lang":"en","type":"review","venue":"Aging Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Université de Sherbrooke; Centre Hospitalier Universitaire de Sherbrooke","funders":"National Institute of Environmental Health Sciences; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Medical Research Council; Wellcome Trust","keywords":"dNaM; Offspring; DNA methylation; Biology; Epigenetics; CpG site; Methylation; Epigenome; Physiology; Genetics; Internal medicine; Pregnancy; Bioinformatics; Demography; Gene; Medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001101991,0.0005892334,0.001757078,0.000320387,0.0001056237,0.0001497752,0.000619188,0.0005251936,0.00001651942],"category_scores_gemma":[0.0003692897,0.0004230186,0.001932329,0.001076277,0.00007930607,0.000005900175,0.0004176347,0.0004099823,0.00008035387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003257483,"about_ca_system_score_gemma":0.0001433488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003420422,"about_ca_topic_score_gemma":0.00007904832,"domain_scores_codex":[0.9963947,0.0004360406,0.001280197,0.001071124,0.0004079128,0.0004100169],"domain_scores_gemma":[0.99692,0.0007151779,0.0008253244,0.001234796,0.000151007,0.0001537258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002413483,0.0004758531,0.0008987566,0.01367245,0.683526,0.0003523956,0.01244181,0.00519945,0.1645315,0.0002931982,0.02769053,0.09089382],"study_design_scores_gemma":[0.0001565553,0.00004771537,0.00008800842,0.0003561691,0.1265484,0.000001170265,0.00006997936,0.00007367709,0.04392008,0.00009816377,0.8285307,0.0001092784],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02031497,0.9744432,0.0003368018,0.00005254164,0.0003341225,0.0005272766,0.0008901778,0.00003206804,0.003068832],"genre_scores_gemma":[0.01526284,0.9719626,0.0008829157,0.0001245385,0.0002233175,0.00005722895,0.001761151,0.0001203095,0.009605082],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8008403,"threshold_uncertainty_score":0.9998221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04182148375132869,"score_gpt":0.3190477634895756,"score_spread":0.2772262797382469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}