{"id":"W4399139465","doi":"10.1111/acel.14194","title":"Maternal age is related to offspring <scp>DNA</scp> methylation: A meta‐analysis of results from the <scp>PACE</scp> consortium","year":2024,"lang":"en","type":"review","venue":"Aging Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Université de Sherbrooke; Centre Hospitalier Universitaire de Sherbrooke","funders":"National Institute of Environmental Health Sciences; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Medical Research Council; Wellcome Trust","keywords":"dNaM; Offspring; DNA methylation; Biology; Epigenetics; CpG site; Methylation; Epigenome; Physiology; Genetics; Internal medicine; Pregnancy; Bioinformatics; Demography; Gene; Medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005961687,0.001206774,0.002987413,0.001535023,0.0006444723,0.001478315,0.001264768,0.001208968,0.002767048],"category_scores_gemma":[0.01222128,0.0007887426,0.01278713,0.003392824,0.0003905966,0.0005978078,0.00108853,0.001445616,0.0002166936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004417024,"about_ca_system_score_gemma":0.0006191122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01138373,"about_ca_topic_score_gemma":0.01159385,"domain_scores_codex":[0.9948248,0.00255593,0.0005210624,0.001420438,0.0004245189,0.0002531988],"domain_scores_gemma":[0.9909581,0.005347298,0.001407799,0.001242969,0.0007003277,0.0003435745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.005374102,0.00003662642,0.5027075,0.006334508,0.469497,0.0004169413,0.0001380508,0.001109658,0.001761184,0.000221676,0.002657399,0.009745384],"study_design_scores_gemma":[0.0006868051,0.0004595499,0.5212063,0.001351128,0.4687089,0.0004664469,0.0001651185,0.001914273,0.0009538977,0.0005109521,0.003525066,0.00005147087],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.649839,0.323597,0.006281368,0.001626121,0.0007293808,0.0001125999,0.01568861,0.0001965522,0.001929305],"genre_scores_gemma":[0.9816267,0.01347219,0.001135871,0.0004577668,0.0001793897,0.00009457368,0.002594234,0.00006659243,0.0003726724],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.01138373,"threshold_uncertainty_score":0.03152877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04182148375132869,"score_gpt":0.3190477634895756,"score_spread":0.2772262797382469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}